保妇康栓联合重组人干扰素α-2b治疗慢性宫颈炎合并HPV感染患者的效果

Effects of Baofukang suppository combined with recombinant human interferonα-2b in treatment of patients with chronic cervicitis complicated with HPV infection

目的:观察保妇康栓联合重组人干扰素α-2b治疗慢性宫颈炎合并HPV感染患者的效果。方法:选取2019年7月至2021年10月该院妇科门诊收治的86例慢性宫颈炎合并HPV感染患者进行前瞻性研究,按随机数字表法将其分为对照组与观察组各43例。对照组采用重组人干扰素α-2b治疗,观察组在对照组基础上联合保妇康栓治疗,比较两组HPV转阴率、阴道排液消失时间,治疗前后HPV病毒载量、炎性因子[C反应蛋白(CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)]水平和不良反应发生率。结果:观察组HPV转阴率为72.09%(31/43),高于对照组的48.84%(21/43),差异有统计学意义(P<0.05);观察组HPV病毒载量低于对照组,阴道排液消失时间短于对照组,差异有统计学意义(P<0.05);治疗后,两组CRP、IL-6、TNF-α水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:保妇康栓联合重组人干扰素α-2b治疗慢性宫颈炎合并HPV感染患者可提高HPV转阴率,降低HPV病毒载量和炎性因子水平,缩短阴道排液消失时间,其效果优于单纯人干扰素α-2b治疗。

Objective:To observe effects of Baofukang suppository combined with recombinant human interferonα-2b in treatment of patients with chronic cervicitis complicated with HPV infection.Methods:A prospective study was conducted on 86 patients with chronic cervicitis complicated with HPV infection admitted to the gynecological clinic of the hospital from July 2019 to October 2021.They were divided into control group and observation group according to the random number table method,43 cases in each.The control group was treated with recombinant human interferonα-2 b,while the observation group was treated with Baofukang suppository on the basis of that of the control group.The HPV negative conversion rate,the HPV viral load,the vaginal discharge disappearance time,the serum inflammatory index levels[C-reactive protein(CRP),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)],and the incidence of adverse reactions were compared between the two groups.Results:The HPV negative conversion rate in the observation group was 72.09%(31/43),which was higher than 48.84%(21/43)in the control group,and the difference was statistically significant(P<0.05).The HPV viral load in the observation group was lower than that in the control group,the vaginal discharge disappearance time was shorter than that in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of CRP,IL-6 and TNF-αin the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Baofukang suppository combined with recombinant human interferonα-2b in the treatment of the patients with chronic cervicitis complicated with HPV infection can improve the HPV negative conversion rate,reduce the HPV viral load and the serum inflammatory index levels,and shorten the vaginal discharge disappearance time.Moreover,it is superior to single human interferonα-2b treatment.