卡维地洛与美托洛尔治疗老年高血压并发室性心律失常患者的效果比较

Comparison of effects of Carvedilol and Metoprolol in treatment of elderly patients with hypertension complicated with ventricular arrhythmia

目的:比较卡维地洛与美托洛尔治疗老年高血压并发室性心律失常患者的效果。方法:选取2019年2月至2020年3月该院收治的93例老年高血压并发室性心律失常患者进行前瞻性研究,以随机数字表法将其分为研究组46例和对照组47例。研究组予以卡维地洛治疗,对照组予以美托洛尔治疗,比较两组临床疗效,治疗前后收缩压(SBP)、舒张压(DBP)和心率水平,血清学指标[超敏C反应蛋白(hs-CRP)、脑钠肽(BNP)]水平,以及不良反应发生率。结果:研究组治疗总有效率为93.48%(43/46),高于对照组的78.72%(37/47),差异有统计学意义(P<0.05);治疗后,两组SBP、DBP和心率水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);治疗后,研究组hs-CRP、BNP水平均低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:卡维地洛治疗老年高血压并发室性心律失常患者可提高治疗总有效率,降低SBP、DBP、心率和血清学指标水平,效果优于美托洛尔治疗。

Objective:To compare effects of Carvedilol and Metoprolol in treatment of elderly patients with hypertension complicated with ventricular arrhythmia.Methods:A prospective study was conducted on 93 elderly patients with hypertension complicated with ventricular arrhythmia admitted to the hospital from February 2019 to March 2020.They were divided into study group(46 cases)and control group(47 cases)by using the random number table method.The study group was treated with Carvedilol,while the control group was treated with Metoprolol.The clinical efficacy,the levels of systolic blood pressure(SBP),diastolic blood pressure(DBP)and heart rate(HR)before and after the treatment,the serological indicator[high-sensitivity C-reactive protein(hs-CRP),brain natriuretic peptide(BNP)]levels,and the incidence of adverse reactions during the treatment were compared between the two groups.Results:The total effective rate of the study group was 93.48%(43/46),which was higher than 78.72%(37/47)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of SBP,DBP and HR in the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of hs-CRP and BNP in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Carvedilol in the treatment of the elderly patients with hypertension complicated with ventricular arrhythmia can improve the total effective rate of treatment and reduce the levels of SBP,DBP,HR and serological indicators.Moreover,it is superior to Metoprolol treatment.