比阿培南联合胸腺五肽治疗老年重症肺炎的临床研究

Efficacy of Biapenem Combined with Thymopentin in the Treatment of Older Patients with Severe Pneumonia

目的探讨比阿培南联合胸腺五肽治疗老年重症肺炎(SP)的效果及对血清胆碱酯酶(ChE)和过氧化脂质(LPO)的影响。方法选取2017年4月~2019年10月收治的130例老年SP患者为研究对象,采用随机数字表法分为研究组和对照组,各65例。对照组采用比阿培南治疗,研究组在对照组基础上联合胸腺五肽治疗,均治疗14 d。比较两组疗效及临床指标。治疗前后检测动脉血氧分压(PaO_(2))、动脉氧分压与吸入气氧浓度比值(PaO_(2)/FiO_(2))、第1秒用力呼气容积(FEV_(1))、用力肺活量(FVC)、最大呼气流速(PEF)、白细胞计数(WBC)、血清ChE和LPO水平。结果研究组总有效率高于对照组,体温恢复时间、咳嗽咳痰消失时间、肺部啰音消失时间、白细胞恢复时间和X线胸片阴影消失时间均短于对照组(P<0.05);治疗后研究组PaO_(2),PaO_(2)/FiO_(2),FEV,,FVC、PEF、ChE高于对照组(P<0.05),WBC和LPO低于对照组(P<0.05);两组不良反应发生率比较,差异均无统计学意义(P>0.05)。结论比阿培南联合胸腺五肽治疗老年SP有效,可以提高血清ChE水平,降低LPO水平。

Objective To investigate the efficacy of biapenem combined with thymopentin in the treatment of severe pneumonia(SP)in older patients and its effects on serum cholinesterase(ChE)and lipid peroxide(LPO).Methods A total of 130 older patients with SP who were treated from April 2017 to October 2019 were selected,and divided into a study group and a control group by random number table,with 65 cases in each group.The control group was treated with biapenem,and the study group was treated with biapenem and thymopentin.Both groups were treated for 14 days.The efficacy and clinical indicators were compared between the two groups.Arterial partial pressure of oxygen(PaO_(2)),ratio of PaO_(2) to fractional concentration of inspired oxygen(FiO_(2))(PaO_(2)/FiO_(2)),forced expiratory volume in one second(FEVj),forced vital capacity(FVC),peak expiratory flow(PEF),white blood cell count(WBC),and serum ChE and LPO levels were measured before and after treatment.Results The overall response rate in the study group was higher than that in the control group,the time to recovery of body temperature,time to disappearance of cough and sputum,time to disappearance of lung rales,time to recovery of white blood cell count,and time to disappearance of chest X-ray shadow in the study group were shorter than those in the control group(P<0.05).After treatment,PaO_(2),PaO_(2)/FiO_(2),FEV\,FVC,PEF amd ChE in the study group were higher than those in the control group,WBC count and LPO level in the study group were lower than those in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Biapenem combined with thymopentin is effective in the treatment of older patients with SP,which may increase serum ChE level and reduce LPO level.