炎症与心房颤动相关性研究进展

Research Progress on the Relationship Between Inflammation and Atrial Fibrillation

心房颤动,简称房颤,是临床最常见的心律失常,可增加脑卒中、痴呆、心力衰竭、心肌梗死等疾病的发病率,增加社会负担。如何预防房颤的发生尤为重要。本文结合新近的研究进展从房颤发病机制、炎症与房颤相互关系(炎性因子参与心房重构、炎性因子预测房颤的发生与进展、炎症与房颤互为因果)进行综述,并进一步探讨抗炎干预,如他汀类药物、多不饱和脂肪酸、糖皮质激素血管紧张素转换酶抑制剂/血管紧张素受体拮抗剂及秋水仙碱对预防和治疗房颤的重要意义。

Atrial fibrillation(AF)is the most common arrhythmia in clinical practice,which can increase the incidence of stroke,dementia,heart failure,myocardial infarction and other diseases,and increase the social burden.How to prevent the occurrence of AF is particularly important.This article reviewed the pathogenesis of AF,the relationship between inflammation and AF(inflammatory factors participate in atrial remodeling,inflammatory factors predict the occurrence and development of AF,inflammation and AF are causally related).Anti-inflammatory interventions,such as statins,polyunsaturated fatty acids,glucocorticoids,angiotensin converting enzyme inhibitor,angiotensin receptor blocker and colchicine for the prevention and treatment of AF were discussed also.