马栗种子提取物治疗下肢深静脉血栓后综合征的效果分析

Analysis of the effect of horse chestnut seed extract in the treatment of lower extremity deep vein post-thrombotic syndrome

目的探讨马栗种子提取物治疗下肢深静脉血栓后综合征(PTS)的临床疗效。方法选取2019年11月至2020年10月深圳大学第一附属医院/深圳市第二人民医院收治的100例静脉回流障碍患者,按照随机数字表法将患者分为试验组与对照组,每组50例。对照组患者接受常规抗凝药物治疗和穿弹力袜,试验组患者在常规抗凝药物治疗和穿弹力袜的基础上加服马栗种子提取物。比较两组患者治疗前与治疗后2周、1个月、3个月、6个月的Villalta评分,以及两组患者治疗后2周、1个月、3个月、6个月的临床疗效。观察两组患者是否出现恶心、呕吐、腹痛、腹胀等胃肠道反应和其他不良反应。结果治疗前,两组患者的Villalta评分比较,差异无统计学意义(P>0.05)。治疗后2周、1个月、3个月、6个月,试验组患者的Villalta评分均低于对照组患者,差异均有统计学意义(P<0.05)。治疗后1、3、6个月,试验组有明显治疗效果的患者分别为43例、50例、50例。治疗后2周,两组患者的临床疗效比较,差异无统计学意义(P>0.05);治疗后1、3、6个月,两组患者的临床疗效比较,差异均有统计学意义(P<0.05)。结论在常规抗凝药物治疗联合穿弹力袜的基础上加服马栗种子提取物对下肢深静脉PTS的临床疗效显著,有利于促进下肢深静脉PTS患者临床症状的缓解,提高患者的生活质量,值得临床推广。

Objective To investigate the clinical efficacy of horse chestnut seed extract in the treatment of lower extremity deep vein post-thrombotic syndrome(PTS).Method A total of 100 patients with venous reflux disorder admitted to the First Affiliated Hospital of Shenzhen University/Shenzhen Second People's Hospital from November 2019 to October 2020 were selected.The patients with venous reflux disorder were divided into the experimental group and the control group according to the random number table method with 50 cases in each group.The patients in the control group received conventional anticoagulant treatment and wore elastic stockings,while the patients in the experimental group received horse chestnut seed extract based on the conventional anticoagulant treatment combined with wearing elastic stockings.The Villalta scores were compared between the two groups before treatment and at 2 weeks,1 month,3 months,and 6 months after the treatment.The clinical efficacy of 2 weeks,1 month,3 months,and 6 months after treatment in the two groups was also compared.The two groups of patients were observed whether nausea,vomiting,abdominal pain,abdominal distension,and other gastrointestinal reactions and other adverse events occurred.Result Before treatment,there was no significant difference in Villalta scores between the two groups(P>0.05).At 2 weeks,1 month,3 months,and 6 months after the treatment,the Villalta scores of the experimental group were lower than those of the control group,and the differences were statistically significant(P<0.05).At 1,3,and 6 months after the treatment,43 cases,50 cases,and 50 cases of the experimental group achieved obvious therapeutic effects.At 2 weeks after the treatment,there was no significant difference in the clinical efficacy between the two groups(P>0.05).At 1,3 and 6 months after the treatment,the clinical efficacy of the two groups were compared,and the difference were statistically significant(P<0.05).Conclusion Based on the conventional anticoagulant treatment combined with wearing elastic stockings,horse chestnut seed extract could achieve remarkable clinical efficacy in treating lower extremity deep vein PTS.This program is conducive to promoting the relief of clinical symptoms of lower extremity deep vein PTS patients and improving their quality of life,which is worthy of clinical promotion.