斑马鱼幼鱼模型在急性肾损伤研究中的适用性

Applicability of zebrafish larvae in the research of acute kidney injury

斑马鱼作为一种新兴的脊椎模式生物,近来被广泛应用于人类疾病研究。斑马鱼幼鱼前肾解剖结构简单,但在组织结构和分子水平上与哺乳动物后肾相似,并具备同样复杂的生物学功能,损伤后的病变反应与人类肾相似,同时斑马鱼幼鱼具有自身特点和优势,是进行肾发育和肾疾病研究的重要模型。本文从斑马鱼幼鱼前肾的生物学特点、幼鱼肾损伤的病变反应机制及在肾损伤研究中的应用优势3方面阐述该模型在急性肾损伤研究中的适用性。

As an emerging vertebrate animal model,zebrafish have been widely used in human disease research.Although simple in form,the larval pronephros is similar to the mammal kidney in terms of histological structure,gene expression,and functional complexity.Furthermore,the response of zebrafish larvae to kidney damage is similar to that of mammals.Because of their unique features and other advantages,zebrafish larvae present a useful model for research into kidney development and disease.This review discusses the applicability of zebrafish larvae in research into acute kidney injury based on the biological characteristics of the pronephros,the pathogenic mechanisms involved,and the advantages for kidney injury research.