多模态超声在类风湿关节炎动物模型中的应用进展

Advances in the application of multimodal ultrasound in animal models of rheumatoid arthritis

类风湿关节炎(rheumatoid arthritis,RA)是以滑膜炎为主要特征的慢性自身免疫性疾病,可导致关节畸形及功能障碍。RA动物模型能很好地模拟疾病发生发展的病理生理过程,广泛用于RA实验研究。多模态超声技术可以定性、定量诊断RA,监测病情变化,评估药物疗效,引导局部给药及靶向治疗,为RA动物模型研究提供精准方法。该文综述了多模态超声在RA动物模型诊疗中的应用情况。

Rheumatoid arthritis(RA)is a chronic autoimmune disease characterized by synovial inflammation,which can lead to joint deformity and dysfunction.Animal models of RA simulate the pathological and physiological processes of its occurrence and development,and are widely used in RA studies.Multimodal ultrasound technology allows qualitative and quantitative diagnosis of RA,monitors changes in conditions,evaluates drug efficacy,and guides local administration and targeted therapy,providing an accurate evaluation method for research of RA animals.This article reviews the application of multimodal ultrasound in the diagnosis and treatment of RA animal models.