左甲状腺素治疗妊娠期亚临床甲状腺功能减退症的疗效与安全性

Efficacy and safety of levothyroxine in the treatment of subclinical hypothyroidism during pregnancy

目的:对妊娠期亚临床甲状腺功能减退症患者采用左甲状腺素治疗的效果进行探究。方法:选择本院收治的妊娠期亚临床甲状腺功能减退症患者106例纳入研究,选取时间为2019年6月至2020年10月。根据抽签法对这些患者予以分组处理,分为甲组53例和乙组53例。甲组接受常规治疗,乙组在此基础上接受左甲状腺素治疗。对比两组的治疗效果。结果:乙组的总有效率为96.2%,甲组的总有效率为71.7%,乙组的总有效率明显高于甲组(P<0.05);甲组的不良妊娠结局发生率为28.6%,乙组的不良妊娠结局发生率为7.5%,乙组的不良妊娠结局明显低于甲组(P<0.05)。结论:针对妊娠期亚临床甲状腺功能减退症患者采用左甲状腺素治疗效果确切,可以有效减少其母婴并发症,改善其不良妊娠结局。

Objective:To explore the effect of levothyroxine treatment in patients with subclinical hypothyroidism during pregnancy.Methods:106 patients with subclinical hypothyroidism during pregnancy admitted to our hospital were selected for inclusion in the study,and the selection period was from June 2019 to October 2020.According to the lottery method,these patients were divided into groups of 53 cases and group B.Group A received conventional treatment,and group B received levothyroxine treatment on this basis.Compare the treatment effects of the two groups.Results:The total effective rate of group B was 96.2%,the total effective rate of group A was 71.7%,the total effective rate of group B was significantly higher than that of group A(P<0.05);the incidence of adverse pregnancy outcomes in group A was 28.6%,The incidence of adverse pregnancy outcome in group B was 7.5%,and the adverse pregnancy outcome in group B was significantly lower than that in group A(P<0.05).Conclusion:Levothyroxine is effective in treating patients with subclinical hypothyroidism during pregnancy,which can effectively reduce their mother and infant complications and improve their adverse pregnancy outcomes.