白鲜碱型呋喃[2,3-b]喹啉的合成研究进展

Research Progress on the Synthesis of Furo[2,3-b]quinolines of Dictamnine Type

呋喃喹啉特别是呋喃[2,3-b]喹啉,如白鲜碱、吴茱萸春、茵芋碱等,广泛存在于天然产物中,具有抗微生物、抗肿瘤、杀虫、抗阿尔茨海默病、抗炎等生物活性,数十年来其合成研究备受关注。目前,该类化合物最主要的合成策略大致可以分为两类:一是在喹啉环的基础上构建呋喃环,另一种是在呋喃环的基础上构建喹啉环。本文就白鲜碱型呋喃[2,3-b]喹啉化合物的合成方法进行较为系统的总结,并展望其研究前景。

Furoquinoline,especially furo[2,3-b]quinoline,such as dictamnine,evolitrine,and skimmianine,is widely found in natural products,and has biological activities such as antimicrobial,antitumor,insecticidal,Alzheimer's disease and anti-inflammatory.Its synthesis research has attracted much attention for decades.At present,the most important synthetic strategies for these compounds can be roughly divided into two categories:one is to construct a furan ring based on a quinoline ring,and the other is to construct a quinoline ring based on a furan ring.In this paper,a systematic summary of the synthesis methods of dictamnine type furo[2,3-b]quinoline compounds was carried out,and their research prospects were proposed.