银屑病病证结合模型的研究进展

Research progress of disease-syndrome combination models of psoriasis

银屑病是一种具有多基因遗传背景的慢性炎症性皮肤病,免疫系统紊乱是银屑病炎症发展和持续的原因,目前认为IL-23/Th17轴的过度激活是其主要发病机制。银屑病以红斑、鳞屑、浸润为主要特征,部分患者反复发作,给个人带来巨大的心理和经济负担。2018版中国银屑病诊疗指南指出,银屑病基本证型为血热证、血瘀证、血燥证、热毒炽盛证、湿热蕴结证、风湿痹阻证,临床治疗需要依据不同证型辨证施治,因此银屑病的病证结合动物模型是研究中医治疗银屑病的重要基础。目前银屑病模型较多,而病证结合动物模型尚未形成体系,不能全面、整体的反映中医“证”的表现。本文对现有的病证结合模型进行了总结,以期为银屑病辨证论治研究提供较为全面的基础支持。

Psoriasis is a chronic inflammatory skin disease with a polygenic genetic background.Disorder of the immune system is the cause of the development and persistence of psoriasis inflammation.It is believed that overactivation of the IL-23/Th17 axis is the main pathogenesis of psoriasis.Psoriasis is mainly characterized by erythema,scale,and infiltration,and some patients have recurrent attacks,which cause psychological and economic burdens to individuals.The 2018 edition of the Chinese guidelines for the diagnosis and treatment of psoriasis indicated that the basic syndrome types of psoriasis are blood-heat syndrome,blood stasis syndrome,blood dryness syndrome,heat-toxin syndrome,dampness-heat accumulation syndrome,and rheumatism obstruction syndrome.Clinical treatment needs to be based on the syndrome types of dialectical treatment.Therefore,the disease and syndrome of psoriasis combined with an animal model is an important basis to study traditional Chinese medicine in the treatment of psoriasis.There are many psoriasis models,but a combination of disease and syndrome animal model has not been established,which cannot fully and comprehensively reflect the performance of a traditional Chinese medicine syndrome.This review summarizes the existing disease-syndrome combination models to provide comprehensive basic support for the research of syndrome differentiation and treatment of psoriasis.