南蛇藤化学成分研究

Chemical constituents from the stems of Celastrus orbiculatus

目的研究南蛇藤Celastrus orbiculatus的化学成分。方法乙醇提取物用硅胶柱、半制备型高效液相等色谱方法进行分离纯化,根据理化性质及波谱数据鉴定所得化合物的结构。结果从中共分离得到8个化合物,分别为7-hydroxy-3-[(4-methoxyphenyl)methoxy]-4 H-1-benzopyran-4-one(1)、桦木酸(2)、platanic acid(3)、金色酰胺醇酯(4)、3-去氧苏木查尔酮(5)、异甘草素(6)、bonducelin(7)、7-羟基-3(4-羟基亚苄基)色满-4-酮(8)。结论化合物1为一新化合物;化合物2、3、5~8为首次从南蛇藤属植物中分离得到的化合物。

AIM To study the chemical constituents from the stems of Celastrus orbiculatus Thunb.METHODS The ethanol extract from C.orbiculatus was isolated and purified by column chromatographies over silica gel and semi-preparative HPLC,then the structures of obtained compounds were identified by physicochemical properties and spectral data.RESULTS Eight compounds were isolated and identified as 7-hydroxy-3-[(4-methoxyphenyl)methoxy]-4 H-1-benzopyran-4-one(1),betulinic acid(2),platanic acid(3),asperglaucide(4),3-deoxysappanchalcone(5),isoliquiritigenin(6),bonducelin(7),(3 E)-2,3-di-hydro-7-hydroxy-3-[(4-hydroxyphenyl)methylene]-4 H-1-benzopyran-4-one(8).CONCLUSION Compound 1 is a new compound.Compound 2,3,5-8 were identified from genus Celastrus for the first time.