HLA-G基因3'UTR多态性与类风湿关节炎发病相关性的Meta分析

Meta-analysis of the relationship between 3’UTR polymorphism of HLA-G gene and the susceptibility to rheumatoid arthritis

本研究选用Meta分析的方法对HLA-G基因3'UTR的2个多态位点14 bp I/D和+3142G/C多态性与类风湿关节炎(rheumatoid arthritis,RA)发病的相关性进行系统评价,以探究RA发病遗传背景的循证医学证据。全面检索PubMed、中国知网、万方数据库中HLA-G基因14 bp I/D和+3142G/C与RA关系的病例对照研究,最终纳入符合要求的文献7篇,研究数据包括病例组1411例、对照组1526例。使用RevMan 5.3软件对筛选出的符合要求的文献进行Meta分析。结果显示,HLA-G基因14 bp I/D与RA发病不相关,+3142G/C隐性纯合突变与RA发病相关(GG vs GC+CC:OR=1.34,95%CI 1.09~1.65,P=0.006)。根据人种进行亚组分析,发现HLA-G基因14 bp I/D与南美洲人群、高加索人群和东亚人群的RA发病均不相关,+3142G/C隐性纯合突变与高加索人群的RA发病相关(GG vs GC+CC:OR=1.35,95%CI 1.06~1.71,P=0.01)。该研究提示,HLA-G基因+3142G/C隐性纯合突变可能是RA发病的危险因素,且与人种有关;HLA-G基因14 bp I/D尚不能认为与RA发病有关联。

This study aimed to investigate the correlation between 14 bp I/D and+3142 G/C polymorphisms in the 3’UTR of HLA-G gene and the occurrence of rheumatoid arthritis(RA)using Meta-analysis and to provide evidence-based medical support to genetic background research of RA.A systematic search of relevant studies in PubMed,CNKI Database,and Wanfang Chinese Periodical Database produced seven eligible case-control studies that were subjected to the Meta-analysis,including a total of 1411 RA cases and 1526 controls.RevMan 5.3 software was used to conduct a Meta-analysis on the above eligible studies.The results showed that HLA-G gene 14 bp I/D was not associated with susceptibility to RA whereas the GG genotype of the HLA-G gene+3142 G/C polymorphism was correlated with RA in the overall group(GG vs GC+CC:OR=1.34,95%CI 1.09-1.65,P=0.006).Subgroup Meta-analysis revealed a significant correlation between RA and the GG genotype of the HLA-G gene+3142 G/C(GG vs GC+CC:OR=1.35,95%CI 1.06-1.71,P=0.01)in the Caucasian population.In contrast,no association was found between the HLA-G gene 14 bp I/D and RA in the South American,Caucasian,and East Asian populations.This Meta-analysis demonstrates that the HLA-G gene+3142 G/C polymorphism is associated with susceptibility to RA in the Caucasian population.And HLA-G gene 14 bp I/D is hard to determine the association of RA.