中药基于SIRT1信号通路干预糖尿病肾病研究进展

Research Progress of Chinese Medicine Intervention on Diabetic Nephropathy Based on SIRT1Signaling Pathway

如今越来越多人饱受糖尿病困扰,而糖尿病肾病(DKD)是其主要的微血管并发症之一,其发病率呈逐年上升趋势。炎症反应、氧化应激、纤维化等皆是糖尿病肾病发生、发展的主要机制。SIRT1作为调控氧化应激、炎症反应及纤维化等机制的一种基因沉默因子,已成为糖尿病肾病防治的关键靶点。中药复方如加味黄风汤、玉液汤、益肾颗粒等,以及中药提取物木犀草素、黄芩苷、甘草酸、丹酚酸B、三七皂苷等均可通过调控SIRT1相关通路发挥其延缓糖尿病肾病发生与发展的作用。通过对近年来中药基于SIRT1相关通路对DKD干预治疗的研究进行梳理,以期为中药基于SIRT1信号通路治疗DKD提供理论依据。

Nowadays,more and more people are suffering from diabetes.As a major microvascular complication,the incidence rate of DKD is increasing year by year.Inflammatory reaction,oxidative stress and fibrosis are the main mechanisms of the occurrence and development of diabetic nephropathy.As a gene silencing factor regulating oxidative stress,inflammation and fibrosis,SIRT1has become a key target for the prevention and treatment of diabetic nephropathy.Chinese herbal compound such as Jiawei Huang Feng Tang,Yuli decoction,Yishen granule,and luteolin,baicalin,glycyrrhizic acid,salvianolic acid B,saponins of panax notognseng,etc.,can play a role in slowing down the occurrence and development of diabetic nephropathy through regulating SIRT1related pathways.To review the research progress of traditional Chinese medicine in the intervention treatment of DKD based on SIRT1related pathways in recent years,in order to provide a theoretical basis for the further exploration of traditional Chinese medicine in the treatment of DKD based on SIRT1signal pathway.