膀胱原发性副神经节瘤8例诊治分析

Diagnosis and treatment of 8 cases of primary paraganglioma of bladder

目的:分析膀胱副神经节瘤的临床诊疗方法,以提高其诊疗技术水平。方法:回顾性分析2011年6月—2021年8月徐州市中心医院和蚌埠医学院第一附属医院收治的8例膀胱副神经节瘤患者的临床资料和随访结果。结果:所有患者术后病理结果均提示膀胱副神经节瘤,免疫组织化学染色标志物突触素(Syn)、瘤细胞嗜铬素A(CgA)均为阳性。术后随访3~126个月,平均59.3个月,8例患者均存活,术后无明显并发症,7例无复发,1例复发。结论:膀胱副神经节瘤临床易诊断,结合临床表现、影像学、膀胱镜可初步诊断,病理诊断可确诊。手术是治疗膀胱副神经节瘤的有效手段,术后并发症少,不易复发,能有效提高患者生活质量。

Objective:To analyze the clinical diagnosis and treatment methods of paraganglioma of bladder,so as to improve the diagnosis and treatment.Methods:The clinical data and follow-up results of 8 patients with paraganglioma of bladder admitted to Xuzhou Central Hospital and First Affiliated Hospital of Bengbu Medical College from June 2011 to August 2021 were retrospectively studied.Results:Postoperative pathological results of all patients in this study indicated paraganglioma of bladder,and immunohistochemical staining marker synaptophysin(Syn) and chromogranin A(CgA) were positive.The patients were followed up for 3-126 months with an average of 59.3 months.All 8 patients survived without significant postoperative complications,and only 1 patient had recurrence.Conclusion:Bladder paraganglioma is easy to be diagnosed clinically,and bladder paraganglioma can be preliminarily diagnosed through cystoscopy combined with clinical manifestations and imaging results.However,its final diagnosis relies on pathology.Surgery is an effective means to treat bladder paraganglioma for its less postoperative complications,low recurrence rate and satisfactory patients’ quality of life.