非创伤性股骨头坏死血清网膜素-1的表达及临床意义

Serum Omentin-1 Changes in Osteonecrosis of the Femoral Head

目的:分析血清网膜素-1(Omentin-1)水平变化与非创伤性股骨头坏死(NONFH)的关系。方法:研究纳入NONFH患者82例为患者组和健康体检者77例作为健康人组,检测两组血清网膜素-1、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)水平。对比不同病因、ARCO分期、塌陷前后血清网膜素-1水平,分析血清网膜素-1水平与疾病严重程度及血脂水平的相关性,使用ROC曲线评估血清网膜素-1浓度在病情评估中的价值。结果:NONFH血清网膜素-1水平显著低于健康对照组,差异有统计学意义(P<0.01);不同病因股骨头坏死患者之间网膜素-1水平差异没有统计学意义(P=0.806);股骨头塌陷后血清网膜素-1水平显著低于塌陷前(P<0.01),双侧发病患者血清网膜素-1水平低于单侧发病,但差异没有统计学意义(P=0.087);不同ARCO分期患者之间血清网膜素-1水平存在显著差异(P<0.01),且血清网膜素-1水平与ARCO分期呈负相关,与VAS评分呈负相关,与Harris评分呈正相关(P<0.01);血清网膜素-1水平与TC、TG水平呈负相关,与HDL水平呈正相关。ROC曲线分析提示血清网膜素-1水平在诊断NONFH中有一定意义。结论:血清网膜素-1水平降低可反映NONFH疾病严重程度,对NONFH的临床诊疗具有一定意义。

Objective:To analyze the relationship between serum retinol-1(Omentin-1)and non-traumatic osteonecrosis of the femoral head(NONFH).Methods:The study included 82 patients with NONFH as the patient group and 77 healthy subjects as the healthy group,and serum retinoid-1,total cholesterol(TC),triglyceride(TG),high-density lipoprotein(HDL),and low-density lipoprotein(LDL)levels were measured in both groups.Serum omentin-1 levels were compared between different etiologies,ARCO stages,and before and after collapse,and the correlation between serum omentin-1 levels and disease severity and lipid levels was analyzed to assess the value of serum omentin-1 concentrations in disease assessment using ROC curves.Results:The level of serum retinin-1 in NONFH was significantly lower than that in healthy controls(P<0.01),but there was no significant difference among patients with osteonecrosis of the femoral head(P>0.05).The level of serum retinin-1 in patients with femoral head collapse was significantly lower than that before collapse(P<0.01).The level of serum retinin-1 in patients with bilateral disease was lower than that in patients with unilateral disease,but the difference was not statistically significant(P>0.05).There was a significant difference in the level of serum retinol-1 among patients with different ARCO stages,and the level of serum retinin-1 was negatively correlated with ARCO stage,VAS score and Harris score,and negatively correlated with TC,TG and HDL.ROC curve analysis showed that the level of serum retinin-1 had a certain significance in the diagnosis of NONFH.Conclusion:The decrease of serum retinol-1 level can reflect the severity of NONFH disease and has certain significance for the clinical diagnosis and treatment of NONFH.