行PCI治疗绝经期女性ACS患者术前血脂水平情况及冠状动脉病变Syntax评分结果分析

Analysis of Preoperative Blood Lipid Levels and Coronary Artery DiseaseSyntax Score in Postmenopausal Women with ACS Undergoing PCI

目的:探讨绝经期女性急性冠脉综合征(ACS)患者应用冠状动脉介入(PCI)治疗的术前血脂水平的状况分析,以及冠状动脉病变Syntax评分情况,为临床治疗提供有利依据。方法:选取本院2020年6月至2021年6月经我院介入治疗的126例绝经期女性ACS患者,将其分为对照组(急性ST段抬高型心肌梗死34例)与观察组(非ST段抬高型急性冠脉综合征92例),分析两组患者的术前血脂水平的变化情况,同时分析两组患者的冠状动脉病变Syntax评分状况。结果:观察组患者的绝经年龄、高血压病史、糖尿病史、吸烟史、TC、TG指标差异均有统计学意义(P<0.05)。两组患者的HDL-C、LDL-C水平分层、Syntax评分差异均无统计学意义(P>0.05)。对照组Syntax评分重度病变较轻度、中度病变LP(a)水平高,中度病变较轻度病变LP(a)水平高,差异均有统计学意义(P<0.05)。但观察组Syntax评分重度病变较轻度、中度病变LDL-C、LP(a)、TG水平高,中度病变较轻度病变LDL-C、LP(a)、TG水平高,差异均有统计学意义(P<0.05);载脂蛋白B/载脂蛋白Al(APOB/APOAI)在重度病变较轻度、中度病变高,差异有统计学意义(P <0.05)。结论:经冠脉介入治疗绝经期女性急性冠脉综合征患者,较为重要的血脂指标为APOB/APOAI、LP(a)、LDL-C、TG,临床应进一步加以研究,为治疗提供有效依据。

Objective:To investigate the status of preoperative blood lipid levels and the Syntax score of coronary artery lesions in postmenopausal women with acute coronary syndrome(ACS)patients undergoing coronary intervention,so as to provide a favorable basis for clinical treatment.Methods:A total of 126 postmenopausal female ACS patients who underwent interventional therapy in our hospital from June 2020 to June 2021 were selected and divided into control group(34 cases of acute ST-segment elevation myocardial infarction)and observation group(92 cases of acute coronary syndrome with non-ST segment elevation),the changes of preoperative blood lipid levels in the two groups of patients were analyzed,and the Syntax score of coronary artery lesions in the two groups of patients was also analyzed.Results:There were significant differences in menopause age,history of hypertension,diabetes history,smoking history,TC and TG indexes in the observation group(P<0.05).There was no significant difference in HDL-C,LDL-C level stratification and Syntax score between the two groups(P>0.05).In the control group,the level of LP(a)in severe lesions was higher than that in mild and moderate lesions,and the level of LP(a)in moderate lesions was higher than that in mild lesions,and the differences were statistically significant(P<0.05).However,in the observation group,the levels of LDL-C,LP(a)and TG in the severe lesions were higher than those in the mild and moderate lesions,and the levels of LDL-C,LP(a)and TG in the moderate lesions were higher than those in the mild lesions.Statistical significance(P<0.05).Apolipoprotein B/Apolipoprotein Al(APOB/APOAI)in the severe lesion was higher than that in the mild and moderate lesions,and the difference was statistically significant(P<0.05).Conclusion:In the treatment of postmenopausal women with acute coronary syndrome by coronary intervention,the more important blood lipid indicators are APOB/APOAI,LP(a),LDL-C,and TG,which should be further studied in clinical practice to provide an effective basis for treatment.