HPLC法检测婴幼儿与成人护肤品中防腐剂添加情况的研究

Study on the detection of preservatives in infant and adult skin care products by HPLC

为了探究婴幼儿和成人护肤品中防腐剂添加情况,以期为婴幼儿和成人护肤品中防腐剂的安全监控与质量研究积累科学数据。以市售的140批护肤类产品为研究对象,基于国家药品监督管理局2021年第17号通告为检验依据对样品中防腐剂进行检测,将检测结果统计分析。结果表明:线性相关系数均大于等于0.9969,加标回收率为91%~104%,RSD小于5.0%。产自广东省和上海市的样本较多,未出现超限度情况,未检出禁用组分。苯氧乙醇和尼泊金酯类的甲丙酯使用频率较高;苯氧乙醇在婴幼儿护肤品中使用率较高;甲丙酯均在驻留类产品中普遍复合添加,且成人护肤品中的使用率高。婴幼儿护肤品中单批样品检出1~3种组分最多共有54批,成人护肤品中单批样品检出1~3种组分最多共有62批。婴幼儿护肤品防腐剂使用量0~2.3%明显高于成人护肤品使用量。结论:该试验下婴幼儿与成人护肤类产品中多以添加1~3种防腐剂成为防腐主流,且以苯氧乙醇和尼泊金酯类的甲丙酯为主要组分。

The situation of addition of preservatives in infant and adult skin care products was studied,which is expected to accumulate scientific data for the safety monitoring and quality research of preservatives therein.12 preservatives were detected for 140 batches of skin care products based on the method for 23 preservatives as shown in the“Technical Specification for Safety of Cosmetics”(2015 edition)(Announcement No.17 of 2021,National Medical Products Administration).The test results were statistically analyzed.The results showed that,the linear correlation coefficients were all greater than or equal to 0.9969,the recovery rate of standard addition was 91%-104%,and the RSD was less than 5.0%.There were many samples from Guangdong Province and Shanghai,and no over-limits or prohibited components were detected.Phenoxyethanol,methylparaben and propylparaben are more frequently used;phenoxyethanol is frequently used in infant skin care products;methylparaben and propylparaben are commonly compounded in retention products,and the frequency of use in adult skin care products is high;the mixture of methylchloroisothiazolinone,methylisothiazolinone,magnesium chloride and magnesium nitrate has only been added to rinse-off products.There are a maximum of 1-3 components in a single batch of infant skin care products of 54 batches,and a maximum of 1-3 components in a single batch of samples in adult skin care products of 62 batches.The amount of preservatives in infant skin care products(0-2.3%)is significantly higher than that of adult skin care products(0.00016%-1.19%).In this test,presence of 1-3 preservatives in infant and adult skin care products has become the mainstream,and phenoxyethanol,methylparaben and propylparaben are the main preservative components.