妊娠期糖尿病患者在孕期补充维生素D_(3)对其T淋巴细胞亚群的影响分析

Effect of vitamin D_(3) supplementation on T lymphocyte subsets in gestational diabetes mellitus patients during pregnancy

目的探讨妊娠期糖尿病患者在孕期做好维生素D_(3)补充,对改善其胰岛抵抗及T淋巴细胞亚群的影响。方法选取在本院建档的妊娠期糖尿病患者80例,随机将其分为对照组和研究组各40例。其中对照组患者给予常规指导,研究组患者在常规指导基础上积极补充维生素D_(3)进行口服补充,对比两组患者治疗参数、T淋巴细胞亚群参数、妊娠结局差异。结果经过干预管理后,研究组血糖水平下降表现更明显,其空腹血糖为(4.08±0.39)mmol/L明显低于对照组,患者25-OH-D_(3)水平为(82.57±3.16)mmol/L要高于对照组,比较差异具有统计学意义(P<0.05)。比较两组T淋巴亚群指标,研究组CD3^(+)、CD4^(+)、CD8^(+)及CD4^(+)/CD8^(+)值与对照组比较,差异具有统计学意义(P<0.05)。比较组间炎性因子指标检测结果,研究组IFN-γ、TNF-α水平更低,其IL-4水平要高于对照组,研究组最终妊娠时顺产率更高,比较差异具有统计学意义(P<0.05)。结论通对孕期妊娠期糖尿病患者适当给予口服维生素D_(3)进行维生素补充,可有效改善其血糖代谢能力,降低糖尿病发生率,对降低围产期母婴不良结局的发生率有积极影响。

Objective To investigate the effect of vitamin D_(3)supplementation on improving islet resistance and T lymphocyte subsets during gestational diabetes mellitus.Methods A total of 80 patients with gestational diabetes mellitus who were registered in our hospital selected and randomly divided into the control group and the study group with 40 cases in each group.The patients in the control group were given routine guidance,and the patients in the control group were actively supplemented with vitamin D_(3)on the basis of routine guidance for oral supplementation.The differences in treatment parameters,T lymphocyte subsets parameters,and pregnancy outcomes were compared between the two groups.Results After intervention and management,the blood glucose level of the study group decreased more obviously,the fasting blood glucose was(4.08±0.39)mmol/L was significantly lower than that of the routine group,and the 25-OH-D_(3)level of the patients was(82.57±3.16)mmol/L.higher than the conventional group,and the difference was statistically significant(P<0.05).Comparing the indicators of T lymphocyte subsets between the two groups,the values of CD3^(+),CD4^(+),CD8^(+)and CD4^(+)/CD8^(+)in the study group were and In the conventional group,the difference was statistically significant(PV0.05).Comparing the detection results of inflammatory factor indexes between the groups,the levels of IFN-γand TNF-αin the study group were lower,and the level of IL-4 was higher than that in the conventional group.(P<0.05).Conclusion Vitamin GDM supplementation can effectively improve the blood glucose metabolism and reduce the incidence of diabetes in pregnant women with gestational diabetes mellitus(GDM).It has a positive effect on reducing the incidence of adverse outcomes in perinatal period.