血必净注射液联合西药治疗重症肺炎患者的临床疗效

Clinical Effect of Xuebijing Injection Combined with Western Medicine on Patients with Severe Pneumonia

目的 探讨血必净注射液联合西药治疗重症肺炎患者的临床疗效。方法 将2019年5月至2021年5月于大连市中医医院重症病房治疗的150例热陷心包型重症肺炎患者通过随机数字表法分为观察组和对照组,各75例。对照组给予西药常规治疗,观察组在对照组西药基础上联合血必净注射液治疗,疗程均为7 d。记录两组患者中医证候治疗有效率、中医证候积分、临床肺部感染评分(CPIS)的主要疗效指标,及包含体温恢复及咳嗽缓解时间、D-二聚体(D-D)、肿瘤坏死因子-α(TNF-α)、降钙素原(PCT)、C反应蛋白(CRP)、白细胞计数(WBC)、白细胞介素-8(IL-8)、白细胞介素-6(IL-6)和血氧分压(PO2)等的次要疗效指标。结果 观察组和对照组中医证候治疗有效率分别为90.7%和76%,观察组疗效更佳(P<0.05)。两组治疗后CPIS及中医证候积分均较治疗前下降(P<0.05),观察组下降更显著(P<0.05)。观察组咳嗽、发热缓解时间均短于对照组(P<0.05)。两组患者治疗后CRP、WBC、PCT、IL-6及IL-8水平均较治疗前下降(P<0.05),PO2较治疗前上升(P<0.05),观察组各项炎症指标和PO2水平改善均优于对照组(P<0.05)。结论 血必净注射液联合西药治疗重症肺炎患者效果显著,可有效控制感染,缓解临床症状,缩短病程。

Objective To explore the clinical effect of Tanreqing injection combined with western medicine on patients with severe pneumonia. Methods From May 2019 to May 2021, 150 patients with multi-drug resistant pneumonia of phlegm-heat obstructing lung type were randomly divided into observation group(75 cases) and control group(75 cases). The control group was treated with conventional western medicine, and the observation group was treated with Xuebijing Injection on the basis of Western medicine in the control group. The course of treatment was 7 days. The main curative effect indexes recorded in the two groups include the clinical curative effect of TCM syndromes, integral of TCM syndromes and clinical pulmonary infection score(CPIS),while the secondary curative effect indexes included temperature recovery and cough relief time, D-Dimer(D-D), tumor necrosis factor-α(TNF-α)、Procalcitonin(PCT), C-reactive protein(CRP), leukocyte count(WBC), interleukin-8(IL-8), interleukin-6(IL-6),and partial pressure of blood oxygen(PO2). Results The effective rates of the observation group and the control group were 90.7%and 76%, respectively, and the observation group had better curative effect(P<0.05). After treatment, the scores of CPIS and TCM syndromes in the two groups decreased, especially in the observation group(P<0.05). The relieving time of cough and fever in the observation group was shorter than that in the control group(P<0.05). After treatment, the levels of PCT, CRP, WBC, IL-6 and IL-8 decreased and PO2 increased in both groups(P<0.05), the improvement of inflammatory indexes and PO2 level in the observation group was better than that in the control group(P<0.05). Conclusion Xuebijing injection combined with western medicine can significantly control infection, relieve clinical symptoms and shorten the course of disease.