铜绿假单胞菌Ⅲ型分泌系统效应蛋白的作用及机制研究进展

Research progress on effect of the effector protein of type Ⅲ secretion system of Pseudomonas aeruginosa and its mechanism

铜绿假单胞菌(PA)是一种引起院内感染的革兰阴性病原菌,PA可通过Ⅲ型分泌系统(T3SS)将效应蛋白转入宿主细胞内而引起急性感染,并在效应蛋白的作用下逃避吞噬细胞的吞噬作用。因此,明确T3SS及其效应蛋白的激活、调控机制有助于为PA的治疗提供新的思路。本文对T3SS的组成和功能、效应蛋白的分泌方式及作用机制进行综述,旨在为新型抗菌药物的研发提供理论基础。

Pseudomonas aeruginosa(PA)is a gram-negative pathogenic bacterium that causes nosocomial infection,PA can transfer the effector proteins into host cells through the type Ⅲ secretion system(T3SS)to cause acute infection,and it can evade the phagocytosis of phagocytes under the action of effector proteins.Therefore,clarifying the mechanism of activation and regulatory of T3SS and its effector proteins will help to provide new ideas for the treatment of PA.This article reviews the composition and function of T3SS,the secretion mode and mechanism of effector proteins,in order to provide a theoretical basis for the development of new antibacterial drugs.