AECOPD发生肺部感染的危险因素及痰热清疗效分析

Risk factors of lung infection in AECOPD and analysis of efficacy Tanreqing

目的探究慢性阻塞性肺疾病急性加重期(AECOPD)发生肺部感染危险因素及痰热清联合常规治疗疗效及安全性。方法选取156例AECOPD患者,感染者50例,未感染者106例。1∶1倾向性评分匹配(PSM)方法分为对照组(n=78)和研究组(n=78);Logistic分析影响AECOPD发生肺部感染危险因素;比较对照组和研究组治疗效果。结果Logistic结果显示,年龄、病程、一年内COPD住院次数是AECOPD肺部感染危险因素(P<0.05);相较对照组,研究组治疗总有效率明显增高,复发率降低(P<0.05);治疗后研究组肺功能和动脉血气指标改善更为显著(P<0.05)。结论年龄、病程、一年内因慢性阻塞性肺病COPD住院次数及治疗方案是影响AECOPD患者发生肺部感染的危险因素;痰热清注射液可改善患者肺功能,降低再入院率。

Aim To investigate the risk factors of pulmonary infection in acute exacerbation of chronic obstructive pulmonary disease(AECOPD)and the efficacy and safety of Tanreqing combined with conventional treatment.Methods A total of 156 patients with AECOPD were selected,including 50 patients in the infection group and 106 patients in the non-infection group.The subjects were divided into control group(n=78)and study group(n=78)by 1∶1 propensity score matching(PSM)method.Logistic analysis was used to analyze the risk factors of pulmonary infection in AECOPD.The treatment effect was compared between the control group and the study group.Results Logistic results showed that age,course of disease and number of COPD hospitalizations within a year were risk factors for pulmonary infection in AECOPD(P<0.05).Compared with the control group,the total effective rate of the study group was significantly high-er,and the recurrence rate was lower(P<0.05).After treatment,pulmonary function and arterial blood gas indexes in the study group were significantly improved(P<0.05).Conclusion Age,duration of disease,number of hospitalizations for chronic obstructive pulmonary disease(COPD)within one year and treatment plan are the risk factors of pulmonary infection in patients with AECOPD.Tanreqing injection can improve pulmonary function and reduce the readmission rate.