基于线粒体功能障碍探讨补肾健脾化湿法对PCOS-IR作用的研究进展

Research progress on the mechanism of“tonifying the kidney,strengthening the spleen and removing dampness”on PCOS-IR based on mitochondrial dysfunction

多囊卵巢综合征(PCOS)是常见的妇科内分泌疾病,常伴随胰岛素抵抗(IR)。中医理论认为PCOS-IR发病主要与脾肾密切相关,肾亏脾虚、痰湿内蕴是PCOS-IR的基本病机,补肾健脾化湿法是治疗PCOS-IR的重要方法。研究显示线粒体功能异常与PCOS-IR发病密切相关。本文在中医理论指导下,以线粒体功能异常为靶点,探讨补肾健脾化湿法对PCOS-IR的防治作用。

Polycystic ovary syndrome(PCOS)is a common gynecological endocrine disease,often accompanied by insulin resistance(IR).TCM theory holds that the pathogenesis of PCOS-IR is mainly closely related to the spleen and kidney.Kidney deficiency,spleen deficiency and phlegm-dampness are the basic pathogenesis of PCOS-IR and the principle of tonifying kidney,strengthening spleen and removing dampness is an important method to treat PCOS-IR.Studies have shown that mitochondrial dysfunction is closely related to the pathogenesis of PCOS-IR.Under the guidance of traditional Chinese medicine theory,with mitochondrial dysfunction as the target,discusses the prevention and treatment effect of tonifying kidney and invigorating spleen and humidifying method on PCOS-IR.