利培酮联合奥氮平治疗精神分裂症的效果及其对患者血清同型半胱氨酸、脂蛋白a的影响

Therapeutic Effects of Risperidone Combined with Olanzapine against Schizophrenia and the Influence on Serum Levels of Homocysteine and Lipoprotein a

目的分析利培酮及奥氮平治疗精神分裂症对患者的症状和血清同型半胱氨酸及脂蛋白a水平的影响。方法将75例精神分裂症患者随机分为3组,各25例,给予利培酮单药(A组)、奥氮平单药(B组)及利培酮联合奥氮平(C组)治疗。对比3组治疗前及治疗4、8周后疗效、症状评价量表、生活质量综合评定问卷评分及血清同型半胱氨酸、脂蛋白a水平。结果治疗前3组间各指标水平无统计学差异。治疗4、8周后,3组症状评价量表评分、血清同型半胱氨酸水平下降,生活质量综合评定问卷评分提高(P<0.05),C组症状评价量表评分、血清同型半胱氨酸水平低于A、B组,生活质量综合评定问卷评分高于A、B组(P<0.05);3组血清脂蛋白a水平无统计学差异。结论奥氮平联合利培酮治疗精神分裂症可以更显著地改善患者症状、降低血清同型半胱氨酸水平、提高生活质量,值得在临床推广。

Objective To analyze the clinical effects of risperidone combined with olanzapine against schizophrenia(SCH)and their influence on serum homocysteine(Hcy)and lipoprotein a(LPa)levels of patients.Methods Seventy-five patients with SCH were randomly divided into three groups,with 25 cases in each.The three groups were treated with olanzapine(group A),risperidone(group B)and risperidone combined with olanzapine(group C)respectively.The positive and negative symptoms scale(PANSS)score,GQOLI-74 score,and serum homocysteine(Hcy)and lipoprotein a(LPa)levels were compared before and after treatment.Results There was no significant difference in any indicator between the three groups before treatment.After treatment of four weeks and eight weeks,the PANSS scores and serum Hcy levels decreased,while GQOLI-74 scores increased in the three groups(P<0.05).At the same time,the PANSS scores and serum Hcy levels were lower,while the GQOLI-74 scores were higher in group C than in groups A and B(P<0.05).There was no obvious change of serum LPa in any of the three groups after treatment.Conclusion Olanzapine combined with risperidone can alleviate patients'symptoms,lowering serum Hcy levels,and improve the quality of life during the treatment of SCH,so this approach should be made more accessible.