门冬胰岛素联合地特胰岛素治疗妊娠期糖尿病的临床疗效

Clinical efficacy of insulin aspart combined with insulin detemir in the treatment of gestational diabetes mellitus

目的探讨分析妊娠期糖尿病孕产妇予以门冬胰岛素联合地特胰岛素治疗的临床疗效。方法选取50例妊娠期糖尿病孕产妇,根据随机数字表法分为对照组(24例)与研究组(26例)。对照组予以门冬胰岛素进行治疗,研究组予以门冬胰岛素联合地特胰岛素进行治疗。比较两组孕产妇治疗前后血糖指标、血糖达标时间、低血糖发生情况及母婴不良结局发生情况。结果治疗前,两组孕产妇空腹血糖(FPG)、餐后2 h血糖(2 hPG)及糖化血红蛋白(HbA1c)水平比较,差异无统计学意义(P>0.05);治疗后,研究组孕产妇FPG、2hPG及HbA1c水平均低于对照组,差异具有统计学意义(P<0.05)。研究组孕产妇FPG达标时间、2hPG达标时间均短于对照组,且低血糖发生率7.69%低于对照组的29.17%,差异具有统计学意义(P<0.05)。研究组母婴不良结局发生率低于对照组,差异有统计学意义(P<0.05)。结论妊娠期糖尿病孕产妇予以门冬胰岛素联合地特胰岛素治疗的疗效可靠,能够明显改善孕产妇的血糖水平,并降低血糖、母婴不良结局的发生情况,值得临床推广与应用。

Objective To investigate the clinical efficacy of insulin aspart combined with insulin detemir in pregnant women with gestational diabetes mellitus. Methods 50 pregnant women with gestational diabetes mellitus were selected and divided into control group(24 cases) and study group(26 cases) according to random number table method. The control group was treated with insulin aspartate, and the study group was treated with insulin aspartate combined with insulin detemir. Blood glucose indexes, blood glucose target time, hypoglycemia and adverse outcomes of maternal and infant were compared between the two groups before and after treatment. Results Before treatment, there were no significant differences in fasting blood glucose(FPG),2 h postprandial blood glucose(2 hPG) and glycosylated hemoglobin(HbA1c) levels between the two groups(P>0.05). After treatment, the levels of FPG, 2 hPG and HbA1c in the study group were lower than those in the control group, and the differences were statistically significant(P<0.05). The time to reach the target of FPG and 2 hPG in the study group were shorter than those in the control group, and the incidence of hypoglycemia was 7.69% lower than 29.17% in the control group, and the differences were statistically significant(P<0.05). The incidence of adverse outcomes in the study group was lower than that in the control group,and the difference was statistically significant(P<0.05). Conclusion Insulin aspartate combined with insulin dete in the treatment of pregnant women with gestational diabetes mellitus has reliable efficacy, which can significantly improve the blood glucose level of pregnant women, and reduce the incidence of low blood glucose and adverse maternal and infant outcomes, which is worthy of clinical promotion and application.