全脑放疗联合盐酸安罗替尼治疗肺癌脑转移瘤合并难治性瘤周水肿的短期疗效分析

Short-term effectiveness of whole brain radiotherapy combined with anlotinib in the treatment of brain metastasis in lung cancer patients with refractory peritumoral edema

目的观察全脑放疗联合盐酸安罗替尼治疗肺癌脑转移瘤合并难治性瘤周水肿的有效性和安全性。方法回顾性分析2019—2020年在徐州医科大学附属医院放疗科接受治疗的11例肺癌脑转移患者的临床资料。患者在全脑放疗期间,同步口服盐酸安罗替尼10~12 mg/d,连续口服14 d,评估患者放疗前后的瘤体体积、瘤周水肿、水肿指数、卡氏功能状态(KPS)评分及症状、体征等,并记录治疗期间的不良反应。结果患者放疗后瘤体体积、瘤周水肿、水肿指数、KPS评分均明显改善(P<0.05),总体生活质量有所提高,治疗期间出现的不良反应均可耐受。结论初步观察推断,全脑放疗期间联合盐酸安罗替尼可有效减轻肺癌脑转移患者的瘤周水肿,控制脑转移瘤,改善患者的临床症状及生活质量,且安全性较好。

Objective To observe the effectiveness and safety of whole brain radiotherapy combined with anlotinib in the treatment of brain metastasis in lung cancer patients with refractory peritumoral edema.Methods A total of 11 lung cancer patients with brain metastasis who were treated in Department of Radiotherapy,the Affiliated Hospital of Xuzhou Medical University from 2019 to 2020 were enrolled and their clinical data were retrospectively analyzed.During whole brain radiotherapy,anlotinib was orally administered at a dose of 10-12 mg/d for consecutive 14 days.Their tumor volume,cerebral edema volume,edema index,Karnofsky performance scale(KPS)score,symptoms and signs were evaluated before and after treatment.Adverse reactions during treatment were also recorded.Results After treatment,the tumor volume,cerebral edema volume,edema index and KPS score were significantly improved(P<0.05).Their overall quality of life was improved,and adverse reactions were tolerable.Conclusions Preliminary observation indicates that whole brain radiotherapy combined with anlotinib can effectively reduce peritumoral edema,control brain metastasis,and improve clinical symptoms and quality of life,with good safety.