PD方案联合沙利度胺对多发性骨髓瘤患者免疫功能的影响

Effect of PD regimen combined with thalidomide on immune function in patients with multiple myeloma

目的观察硼替佐米^(+)地塞米松(PD)方案联合沙利度胺(Tha)对多发性骨髓瘤(MM)患者免疫功能的影响。方法选取2018年1月—2021年12月宜春市人民医院收治的62例MM患者,根据随机数字表分为两组,对照组、观察组各31例,对照组接受PD方案治疗,观察组采取PD方案联合Tha治疗,均治疗4个疗程,比较两组化疗效果;于治疗前、治疗4个疗程时,比较两组免疫功能(CD3^(+)、CD4^(+)、CD8^(+)T淋巴细胞水平);记录并比较两组治疗期间毒副反应发生情况。结果观察组总缓解率为93.54%,高于对照组的70.96%(P<0.05);治疗4个疗程时,两组CD3^(+)、CD4^(+)水平显著升高,CD8^(+)显著下降,且观察组CD3^(+)、CD4^(+)高于对照组,CD8^(+)低于对照组(P<0.05)。两组毒副反应发生率比较,差异无统计学意义(P>0.05)。结论PD方案联合Tha治疗MM患者,可提高总缓解率,利于改善患者免疫功能,且毒副反应低。

Objective To observe the effect of bortezomib-dexamethasone(PD)regimen combined with thalidomide(Tha)on the immune function of patients with multiple myeloma(MM).Methods 62 MM patients admitted in Yichun People's Hospital from January 2018 to December 2021 were selected and divided into control group and observation group according to the random number table method,with 31 cases in each of them.The control group was treated with PD regimen,and the observation group received PD regimen combined with Tha treatment;both groups were treated for 4 courses,and the chemotherapy effects were compared between the two groups.The immune functions(CD3^(+),CD4^(+),CD8^(+)T lymphocyte levels)were compared between the two groups before treatment and after completion of 4 treatment courses,and the occurrences of toxic effects during treatment were recorded and compared between the two groups.Results The overall remission rate in the observation group was 93.54%,which was higher than 70.96%in the control group(P<0.05).After completion of 4 courses of treatment,the levels of CD3^(+)and CD4^(+)in the two groups were significantly increased,with CD8^(+)significantly decreased;and the levels of CD3^(+)and CD4^(+)in observation group were higher than that in control group,and the level of CD8^(+)in observation group was lower than that in the control group(P<0.05).There was no statistically significant difference in the incidence of toxic effects between the two groups(P>0.05).Conclusion PD regimen combined with Tha in the treatment of MM patients can improve the overall remission rate and the patients'immune function,and have low toxicity.