基于“脑肠交互”探讨针灸治疗功能性胃肠病的效应机制

Effects Mechanisms of Acupuncture and Moxibustion in Treatment of FGIDs Based on‘Brain-Gut Interaction’

功能性胃肠病是临床常见病症,几千年的临床实践及循证证据表明针灸治疗功能性胃肠病疗效明确、副作用小,但其机制尚未系统阐明。通过文献分析,笔者发现针灸能够通过促进脑肠轴相关脑区功能正常化,调动脑肠轴相关NEI网络中自主神经、HPA轴,调节下游免疫网络及肠道菌群促使胃肠道稳态恢复。此外,针灸可通过抑制痛觉信号传递减轻功能性胃肠病内脏超敏反应。本研究对针灸治疗功能性胃肠病基于“脑-肠”整体水平的效应机制进行了综述,为针灸临床应用提供证据。

Objective:Functional gastrointestinal disorders(FGIDs)are common clinical diseases.Thousands of years of clinical practice and evidence show that acupuncture and moxibustion have definite curative effects and small side effects,but the mechanisms have not been systematically clarified.Through reviewing analysis,the author found that acupuncture and moxibustion can promote the recovery of gastrointestinal homeostasis by mobilizing the autonomic nerve and HPA axis in the brain gut axis,further regulating the downstream immune network and intestinal flora.In addition,acupuncture and moxibustion can reduce visceral hypersensitivity of FGIDs by inhibiting pain signal conduction.This study reviewed the effects mechanisms of acupuncture and moxibustion in treating FGIDs based on‘brain-gut axis’,aiming to provide evidence for the clinical application of acupuncture and moxibustion.