化学-酶法串联一锅合成R-γ-氨基酸

Chemoenzymatic Synthesis of R-γ-Amino Acid in One Pot

为开发简易高效的手性γ-氨基酸合成方法,采用烯丙基胺作为起始底物,在脂肪酶催化下利用酯化动态动力学拆分得到光学纯的烯丙基酰胺,再与α,β-不饱和酸进行一锅烯烃复分解反应制得相应的手性γ-氨基酸.

To develop the convenient and efficient synthesis strategy of chiral γ-amino acids, allylamine was adopted as the starting substrate and the lipase-catalyzed dynamic kinetic resolution was utilized to obtain optical pure allyl-amid. Then, the optical pure allyl-amid reacted with α, β-unsaturated acid to form the chiral γ-amino acids in one pot.