piRNA调节心血管疾病的分子机制进展

Advances in the mechanism of piRNA regulating cardiovascular disease

PIWI-interacting RNA(piRNA)是一类最初从生殖细胞中发现的长约30 nt的新型内源性非编码RNA,能够与PIWI蛋白家族成员结合抑制转座子,保持种系基因组完整性.随着研究的不断深入,piRNA被证实在生殖细胞以外的其他组织细胞中亦可表达,并且在众多的生理病理过程中发挥着重要的调节作用.心血管疾病(cardiovascular disease,CVD)是引发全球人口死亡的首要原因.基于piRNA的生物发生过程深入讨论了其在不同心血管疾病中的作用及潜在机制,归纳了可用于防治及诊断心血管疾病的piRNA发明专利,以期丰富piRNA的分子生物学理论,并为防治心血管疾病提供新靶点和潜在策略.

PIWI-interacting RNA(piRNA),a new type of endogenous non-coding RNA,was identified from germ cells.Approximately 30 nt long,piRNA plays an important role in regulating physical or pathological processes,including maintaining genomic integrity,via interacting with the PIWI protein family.Research advancements confirms that piRNA is widely expressed in several other tissues and cells.Cardiovascular disease(CVD)is a leading cause of mortality worldwide.The present review summarizes the role and underlying mechanism of piRNA in CVD models upon their biogenesis process and tissue distribution.It also examines CVD diagnosis-and treatment-associated patents.These rrsults may help enrich the molecular biological theory of piRNA and provide potential targets and strategies for the treatment of CVD.