摘要
为提高维生素A的稳定性而优化多种维生素矿物质片的生产工艺,通过单因素试验确认以微晶纤维素为填充剂、低取代羟丙基纤维素为崩解剂、共聚维酮为黏合剂,并采用正交试验设计优化配方。试验结果表明,最佳添加量为微晶纤维素6.5%、低取代羟丙基纤维素3.3%、共聚唯酮3.4%。在此工艺条件下,片剂外观、脆碎度及崩解时限均符合质量标准,压片压力大幅降低,维生素A的稳定性得到显著改善。该试验为多种维生素矿物质片的生产工艺优化提供参考方案。
In order to improve the stability of vitamin A, the production process of multi vitamin mineral tablets was optimized through single factor experiment and orthogonal design. It was confirmed that microcrystalline cellulose was used as filler, low substituted hydroxypropyl cellulose was used as disintegrating agent, and copovidone was used as adhesive. The experimental results showed that the maximum additive amount was microcrystalline cellulose 6.5%, low substituted hydroxypropyl cellulose 3.3% and copovidone 3.4%. Under this process condition, the appearance, brittleness and disintegration time of the obtained tablets met the requirements, the tablet pressing pressure was greatly reduced, and the stability of vitamin A was significantly improved. The experiment provided a reference for the optimization of the production process of multi vitamin mineral tablets.
作者
罗碧青
陈强
黄玲
张旭光
蔡良平
LUO Biqing;CHEN Qiang;HUANG Ling;ZHANG Xuguang;CAI Liangping(BYHEALTH Institute of Nutrition&Health,Zhuhai 519040)
出处
《食品工业》
CAS
2022年第9期78-82,共5页
The Food Industry
关键词
多种维生素矿物质片
工艺优化
可压性
单因素试验
正交试验
multi vitamin mineral tablet
process optimization
compressibility
single factor experiment
orthogonal design