Cu@Co双核MOFs衍生碳材料用于黄芩素的电化学传感分析

Cu@Co Binuclear MOFs Derived Carbon Materials for Electrochemical Sensing of Baicalein

采用水热法合成了Cu@Co双核金属有机框架(MOFs)材料,以其为前驱体分别在400、500、600℃热解制备了一类MOFs衍生碳材料,并用作电极修饰材料构建了一种检测黄芩素(BA)的电化学传感器。使用电化学交流阻抗技术(EIS)和循环伏安法(CV)研究了该传感器的电化学性能,并在pH 2.0的磷酸缓冲溶液(PBS)中用微分脉冲伏安法(DPV)和CV法考察了BA在不同电极上的电化学行为。结果表明,600℃热解的MOFs衍生碳材料修饰的电极对BA的检测效果最佳。基于此,建立了一种可定量分析BA的新方法,线性范围为5×10^(-9)~1×10^(-5)mol/L,检出限为1.32×10^(-10)mol/L。通过加标回收法对双黄连口服液样品中的BA进行检测,加标回收范围为99.23%~101.80%。

Cu@Co binuclear metal organic frameworks(MOFs) materials were synthesized by hydrothermal method, and these precursors were used to prepare a class of MOFs-derived carbon materials by pyrolysis at 400, 500 and 600 ℃, respectively. Then,the electrochemical sensors for the detection of baicalein(BA) were constructed by using MOFS-derived carbon materials as electrode modification materials. The electrochemical properties of the sensors were tested by electrochemical impedance spectroscopy(EIS) and cyclic voltammetry(CV), and the electrochemical behavior of BA on different electrodes were investigated by differential pulse voltammetry(DPV) and CV in pH 2.0 phosphate buffer solution(PBS), which turned out that the electrode modified with MOFs-derived carbon material pyrolysis at 600 ℃ showed the best detection effect for BA. Based on this, a new scheme for quantitative analysis of baicalin has been established with the linear detection range of 5×10^(-9)~1×10^(-5)mol/L and the lower detection limit of 1.32×10^(-10)mol/L. When the method is applied to the analysis of BA in Shuanghuanglian oral liquid samples by standard recovery, the recovery range is 99.23%-101.80%.