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左氧氟沙星对淋病伴非淋菌性尿道炎的疗效 被引量:1

Curative effect of levofloxacin on gonorrhea with non-gonococcal urethritis
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摘要 目的 观察不同剂量左氧氟沙星治疗淋病合并非淋菌性尿道炎患者的疗效及血清炎性因子水平,为其临床治疗提供参考。方法 选取天津市滨海新区大港医院2018年7月—2020年7月收治的淋病合并非淋菌性尿道炎患者46例作为研究对象,根据患者入院编号将其分为对照组(单数)和观察组(双数),每组23例。对照组采用常规剂量左氧氟沙星进行治疗,观察组采用大剂量左氧氟沙星治疗。观察两组患者的疗效、血清炎性因子水平及不良反应发生情况。结果 治疗后,观察组总有效率为95.65%,明显高于对照组的73.91%;观察组的白细胞介素-1(IL-1β)、白细胞介素-6(IL-6)及白细胞介素-8(IL-8)水平均低于对照组;观察组不良反应发生率为8.70%,明显低于对照组的34.78%,差异均有统计学意义(P<0.05)。结论 大剂量左氧氟沙星治疗淋病合并非淋菌性尿道炎,不仅可有效降低血清炎症因子水平,还可以降低并发症发生率,提高治疗效果,值得临床推广应用。 Objective To observe the efficacy of different doses levofloxacin in the treatment of patients with gonorrhea complicated with non-gonococcal urethritis and serum inflammatory factor levels,so as to provide the reference for its clinical treatment.Methods A total of 46 patients with gonorrhoea complicated with non-gonococcal urethritis who were admitted to Tianjin Binhai New Area Dagang Hospital from July2018 to July 2020 were selected as the research objects.According to the admission number of the patients,they were divided into control group(odd number)and observation group(even number),with 23 cases in each group.The control group was treated with conventional doses levofloxacin,and the observation group was treated with high-dose of levofloxacin.The efficacy,serum inflammatory factor levels and the occurrence condition of adverse reactions of the two groups were observed.Results After treatment,the total effective rate of the observation group was 95.65%,which was significantly higher than 73.91% of the control group;the levels of serum interleukin-1(IL-1β),serum interleukin-6(IL-6)and serum interleukin-8(IL-8)of the observation group were lower than those of the control group;the incidence of adverse reaction in the observation group was 8.70%,which was significantly lower than 34.78% in the control group,and the differences were statistically significant(P<0.05).Conclusion The treatment of high-dose levofloxacin for gonorrhea complicated with non-gonococcal urethritis could not only effectively reduce the levels of serum inflammatory factors,but also reduce the incidence of complications,and improve the treatment effect,which was worthy of clinical promotion and application.
作者 李殿霞 孙慧芳 LI Dian-xia;SUN Hui-fang(Department of Prevention,Tianjin Binhai New Area Dagang Hospital,Tianjin 300270,China)
出处 《中国城乡企业卫生》 2022年第9期7-10,共4页 Chinese Journal of Urban and Rural Enterprise Hygiene
关键词 左氧氟沙星 淋病合并非淋菌性尿道炎 炎性因子水平 并发症 疗效 Levofloxacin Gonorrhea complicated with non-gonococcal urethritis Inflammatory factor levels Complications Curative effect
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