基于数据挖掘研究治疗心力衰竭中药复方专利的用药规律

Medication Regularity of Chinese Medicine Patent Compounds Against Heart Failure Based on Data Mining

目的:基于中医药传承辅助平台挖掘治疗心力衰竭(HF)中药复方专利的用药规律。方法:登录国家知识产权局中国专利公布公告网站(http://epub.sipo.gov.cn/),检索治疗HF的中药复方专利,运用中医药传承辅助平台V2.5对获得的复方专利中药频次、四气五味、归经、配伍规律、核心药物组合进行分析,并挖掘新方。结果:共纳入治疗HF中药复方专利95个,共206味中药;出现频次最高的药物是黄芪(54次);常用的药对有丹参-黄芪、黄芪-附子、黄芪-茯苓等;四气占比最多的是温性药物;五味占比最多的是甘味;归经占比最多的是脾经;置信度较高的关联规则有丹参、当归->黄芪等;核心药物组合有党参-白术-桂枝等;新方包括党参-白术-桂枝-当归-赤芍-红花、黄芪-甘草-干姜-丹参-灵芝、鸡血藤-三七-橘红-银杏叶、水蛭-补骨脂-土鳖虫-绞股蓝等。结论:治疗HF中药复方专利及新方的主要功效是益气、活血化瘀、利水。基于数据挖掘的研究可为中药临床治疗HF及研发新的药物提供一定数据参考。

Objective:To explore the medication regularity of Chinese medicine patent compounds against heart failure(HF) based on data mining in the Traditional Chinese Medicine Inheritance Support System(TCMISS).Methods:The Chinese medicine patent compounds against HF were searched from China National Intellectual Property Administration(http://epub.sipo.gov.cn/).TCMISS V2.5 was employed to analyze the frequency, four qi, five flavors, meridian tropism, compatibility, and core drug combinations of Chinese medicine patent compounds, and explore new prescriptions.Results:Ninety-five Chinese medicine patent compounds against HF were included, with 206 drugs involved.The drug with the highest frequency of occurrence was Astragali Radix(54 times).The common drug pairs included Salviae Miltiorrhizae Radix et Rhizoma-Astragali Radix, Astragali Radix-Aconiti Lateralis Radix Praeparata, and Astragali Radix-Poria.In terms of four qi and five flavors, drugs were dominated by warm and sweet ones.In terms of meridian tropism, drugs mainly acted on the spleen meridian.As revealed by the association rules, drugs with high confidence were Salviae Miltiorrhizae Radix et Rhizoma, Angelicae Sinensis Radix, and Astragali Radix.The core drug combinations included Codonopsis Radix-Atractylodis Macrocephalae Rhizoma-Cinnamomi Ramulus, etc.New prescriptions included Codonopsis Radix-Atractylodis Macrocephalae Rhizoma-Cinnamomi Ramulus-Angelicae Sinensis Radix-Paeoniae Radix Rubra-Carthami Flos, Astragali Radix-Glycyrrhizae Radix et Rhizoma-Zingiberis Rhizoma-Salviae Miltiorrhizae Radix et Rhizoma-Ganoderma, Spatholobi Caulis-Notoginseng Radix et Rhizoma-Citri Exocarpium Rubrum-Ginkgo Folium, and Hirudo-Psoraleae Fructus-Eupolyphaga Steleophaga-Gynostemmatis Herba.Conclusion:The main functions of Chinese medicine patent compounds and new prescriptions against HF were replenishing qi, activating blood, resolving stasis, and excreting water.The study based on data mining is expected to provide data references for the clinical treatment of HF and the development of new drugs.