环状RNA编码多肽或蛋白质在人类恶性肿瘤增殖机制中的作用

The function of circular RNA-encoded polypeptide or protein in the proliferation mechanism of human malignant tumors

环状RNA由于5′帽状结构的缺失一直被认为是非编码RNA, 不具有编码蛋白或多肽的功能。随着高通量转录组测序、核糖体测序等技术的进展, 研究发现环状RNA的序列中存在短开放阅读框和内部核糖体进入位点, 具有编码多肽或蛋白质的能力, 并在胶质瘤、肝细胞癌、胃癌、乳腺癌、结肠癌等恶性肿瘤增殖中发挥重要作用。现通过综述环状RNA编码功能, 分析其编码产物-多肽或蛋白质在人类恶性肿瘤增殖机制中的作用。

Circular RNA(circRNA)is considered to be non-coding RNA due to the deletion of the 5'cap structure and lacks the function of encoding proteins or polypeptides.With the development of high-throughput transcriptome sequencing,ribosome sequencing and other technologies,researchers have discovered that there were short open reading frames(sORF)and internal ribosome entry sites(IRES)in the sequence of some circRNAs which can encode polypeptides or protein and play important roles in the proliferation of malignant tumors such as glioma,hepatoma,gastric cancer,breast cancer,and colon cancer.This paper reviews the coding function of circRNA and analyzes the role of its encoded production-polypeptides or protein in the proliferation mechanism of human malignant tumors.