非标准抗磷脂抗体与复发性流产的相关性及临床应用研究进展

Research progress on the correlation and clinical application of non-standard antiphospholipid antibodies and recurrent miscarriage

抗磷脂综合征(APS)是复发性流产(RSA)的病因之一,其诊断必须同时满足临床标准和实验室标准。实验室诊断标准中的抗磷脂抗体(aPLs)包括狼疮抗凝物(LA)、抗心磷脂抗体(aCL)和抗β,糖蛋白I抗体(aβ_(2)-GPI)。针对病因的早期用药是RSA的治疗关键,基于这3种aPLs的诊断标准不能完全满足目前的临床诊疗需求。越来越多的研究发现--些非典型aPLs与RSA关系密切,有助于早期预测和干预,防止再次流产发生。本研究就未纳入APS诊断标准的aPLs与RSA的相关性研究进展进行综述,以期提高产科APS的评估效能。

Antiphospholipid syndrome(APS)is one of the main etiologies leading to recurrent spontaneous abortion(RSA).The classification of APS needs to meet clinical and laboratory criteria at the same time.Consensus criteria of aPLs applied currently include lupus anticoagulant(LA),anticardiolipin antibodies(aCL)and anti-β_(2)glycoproteinIantibodies(aβ_(2)-GPI).Early medication for the cause is the key to the treatment of recurrent miscarriage,and the diagnostic criteria based on these three aPLs cannot fully meet the current clinical diagnosis and treatment needs.Recently,more and more non-criteria aPLs are discovered closely referred to RSA.They are very valuable to identify and intervene non-criteria APS patients in advance to avoid spontaneous abortion again.This review evaluated the evidence and clinical relevance of non-criteria aPLs and RSA,in order to improve the evaluation performance of obstetric APS.