卡前列素氨丁三醇对高危剖宫产孕产妇产后出血与血流动力学的影响

Effects of carboprost aminobutyric triol on postpartum hemorrhage and hemodynamics in high-risk cesarean section pregnant women

目的探讨卡前列素氨丁三醇对高危剖宫产孕产妇产后出血与血流动力学的影响。方法选取140例高危行剖宫产的产妇为研究对象,根据随机数字表法分为研究组与对照组,每组75例。对照组给予子宫肌壁注射缩宫素,研究组给予卡前列素氨丁三醇注射液宫体肌内注射。观察两组出血情况、血流动力学、止血效果、药物不良反应。结果两组术中出血量比较,差异无统计学意义(P>0.05);研究组产后2、24 h出血量少于对照组,出血停止时间短于对照组,产后出血发生率低于对照组,差异均有统计学意义(P<0.05)。产前,两组收缩压、舒张压、心率比较,差异均无统计学意义(P>0.05);产后24 h,研究组收缩压、舒张压高于对照组,心率低于对照组,差异均有统计学意义(P<0.05)。研究组优良率为96.00%,高于对照组的85.33%,两组比较差异有统计学意义(P<0.05)。研究组不良反应总发生率为5.33%,低于对照组的16.00%,两组比较差异有统计学意义(P<0.05)。结论针对有高危因素的剖宫产宫术后出血患者应用卡前列素氨丁三醇,可有效降低出血,止血效果好,且无严重不良反应,值得临床推广应用。

Objective To investigate the effect of carboprost tromethamine on postpartum hemorrhage and hemodynamics in high-risk cesarean section pregnant women.M ethods A total of 140 high-risk puerperae who underwent cesarean section were selected as the research objects,and were divided into a study group and a control group according to the random number table method,with 75 cases in each group.The control group was given uterine muscle wall injection of oxytocin,and the study group was given intramuscular injection of carboprost tromethamine injection.The bleeding,hemodynamics,hemostatic effect and adverse drug reactions of the two groups were observed.Results There was no significant difference in intraoperative blood loss between the two groups(P>0.05).The blood loss at 2 hours and 24 hours postpartum in the study group was less than that in the control group,the bleeding stop time was shorter than that in the control group,and the incidence of postpartum hemorrhage was lower than that in the control group,and the differences were statistically significant(P<0.05).Before delivery,there was no significant difference in systolic blood pressure,diastolic blood pressure and heart rate between the two groups(P>0.05).At 24 hours postpartum,the systolic blood pressure and diastolic blood pressure in the study group were higher than those in the control group,and the heart rate was lower than that in the control group,the differences were statistically significant(P<0.05).The total effective rate in the study group was 96.00%,which was higher than 85.33%in the control group,and the difference between the two groups was statistically significant(P<0.05).The total incidence of adverse reactions in the study group was 5.33%,which was lower than 16.00%in the control group,and the difference between the two groups was statistically significant(P<0.05).Conclusion The application of carboprost tromethamine for patients with bleeding after cesarean section with high risk factors can effectively reduce bleeding,hemostatic effect is good,and there is no serious adverse reaction,which is worthy of clinical application.