纳米材料应用于眼科治疗的研究进展

Advances of nanomaterials applied in ophthalmic treatment

纳米材料已应用于眼科治疗的各个领域。本文通过强调纳米粒子及复合物的特性,先阐述了其在药物递送方面较成熟的应用,再综述了它们在再生医学和基因治疗方面的研究,还讨论了纳米材料在眼科医学上应用的主要限制-稳定性、生物毒性和临床前-临床差异。在恰当的运输系统和运用场合开发高效、无毒的纳米材料,将为纳米材料在眼科治疗中的未来应用提供更多可能。

Nanomaterials have been used in many aspects of ophthalmic treatment.By emphasizing the ubiquitous characteristics of nanoparticles and composites,we first explained their relatively mature applications in drug delivery.Then we reviewed the research on nanomaterials in regenerative medicine and gene therapy in recent years.We also discussed the main limitations of the wider application of nanomaterials in ophthalmology:stability,biotoxicity and preclinical-clinical differences.The development of efficient and non-toxic nanomaterials,combined with appropriate transportation systems and application occasions,will provide more possibilities for the future application of nanomaterials in ophthalmic treatments.