Generation of sulfonylureas under photoredox catalysis and their biological evaluations

Traditional synthesis of sulfonylureas largely depends on nucleophilic addition of arylsulfonamides to presynthesized isocyanates.Now we report a new access to alkylsulfonylureas with good yields and broad substrate scope.With the insertion of commercialized chlorosulfonyl isocyanate under photoredox catalysis,alkylsulfonylureas are synthesized in one-pot from the corresponding anilines and silyl enolates.A reaction mechanism is proposed showing the transformation undergoes a radical process,and the practicality of this methodology is proven via application to bioactive molecules.Additionally,the anti-cancer and anti-virus screening of these compounds is evaluated.