帕金森病外周免疫机制研究进展

Research progress on the mechanism of peripheral immunity in Parkinson′s disease

帕金森病是常见的老龄相关中枢神经系统神经退行性疾病,其发病机制为遗传易患因素、环境风险因素共同作用下的一系列病理生理变化。近年研究显示中枢神经系统以外的部位和机制,特别是免疫炎性反应等可能在帕金森病发病过程中起重要作用。我们拟对目前已有的帕金森病外周免疫炎症机制研究结果进行综述,初步探讨其在帕金森病发病过程中的作用。

Parkinson′s disease(PD)is a common aging-related neurodegenerative disease of the central nervous system.Its pathogenesis is a series of pathophysiological changes under the interaction of genetic factors and environmental risk factors.Recent studies have shown that the pathophysiologic mechanisms outside the central nervous system,especially inflammation and immune response,may play an important role in the pathogenesis of Parkinson′s disease.This article aims to review the up-to-date research results of the peripheral origin of PD,and to discuss the interplay and activation of the peripheral inflammatory immune system in PD.