昼夜节律及昼夜节律失调性睡眠觉醒障碍研究进展

Research progress of circadian rhythm and circadian rhythm sleep-wake disorders

昼夜节律由视交叉上核生物钟驱动,许多生命活动与生理功能均受昼夜节律的调节,如中枢神经系统活动、自主神经系统活动、内分泌功能、代谢与免疫功能等。在分子水平上,昼夜节律由生物钟基因震荡产生的分子机制调控。内源性的昼夜节律是控制睡眠的主要过程之一。昼夜节律紊乱可引起多种生理功能异常,最常导致睡眠-觉醒周期异常,也可导致其他睡眠障碍、认知功能异常、高血压、糖尿病及肿瘤等一系列疾病及不良后果。近期,昼夜节律与睡眠觉醒之间的联系日益引起研究者们的关注。文中综述了昼夜节律及昼夜节律失调性睡眠觉醒障碍的研究进展。

Circadian rhythm is driven by the suprachiasmatic nucleus biological clock,and many life activities and physiological functions are regulated by circadian rhythm,such as central nervous system activity,autonomic nervous system activity,endocrine function,metabolism and immune function.At the molecular level,circadian rhythm is regulated by molecular mechanisms generated by clock genes′oscillations.Endogenous circadian rhythm is one of the main processes controlling sleep.Circadian rhythm disorder is the most common cause of abnormal sleep-wake cycle,and can also lead to a series of diseases and adverse consequences such as other sleep disorders,abnormal cognitive function,hypertension,diabetes and tumors.Recently,the relationship between circadian rhythm and sleeping awakening has become a hot topic for researchers.In this paper,the research progress of circadian rhythm and circadian rhythm sleep-wake disorders was reviewed.