鳖甲煎丸在乙型肝炎肝硬化和肝癌中的作用机制及临床进展

Mechanism and Clinical Progress of Biejiajian Pill in Hepatitis B Cirrhosis and Liver Cancer

鳖甲煎丸由东汉末年医圣张仲景所创,具有软坚散结、活血化瘀之效。现代实验研究发现鳖甲煎丸具有抗肝纤维化,抑制肝癌细胞增殖,诱导肝癌细胞凋亡,抑制肝癌细胞侵袭、转移,抑制肝癌血管新生等药理作用,临床多以此方治疗肝病,延长生存期的同时,生活质量亦得到提高,疗效明显。故本文拟就近年来鳖甲煎丸的相关文章进行综合分析,着重围绕鳖甲煎丸在肝病中的作用机制及临床运用展开论述,以期为其今后的实验及临床研究提供新思路。

Biejiajian pill,created by Zhang Zhongjing,a medical sage in the late Eastern Han Dynasty,has the effects of softening and dissolving knots,activating blood circulation and removing blood stasis.Modern experimental studies have found that Biejiajian pills have pharmacological effects such as anti-liver fibrosis,inhibition of liver cancer cell proliferation,induction of liver cancer cell apoptosis,inhibition of liver cancer cell invasion and metastasis,and inhibition of liver cancer angiogenesis.Clinically,this formula is used to treat liver disease,prolong the survival time,and improve the quality of life.Therefore,this article comprehensively analyzes the related articles of Biejiajian pills in recent years,focusing on the mechanism of action and clinical application of Biejiajian pills in liver diseases,in order to provide new ideas for its future experimental and clinical research.