中药热奄包联合运动干预治疗膝骨性关节炎临床观察

Clinical Observation on Chinese Medicine Fomentation Package Combined with Exercise Intervention in the Treatment of Knee Osteoarthritis

目的 研究中药热奄包联合运动干预在膝骨性关节炎中的应用。方法 将82例膝骨性关节炎患者随机均分为观察组(中药热奄包联合运动干预)和对照组(单纯运动干预),比较2组临床疗效、中医证候积分、疾病疼痛程度及炎性因子水平。结果 治疗后,2组临床总有效率分别为92.7%(38/41)和68.3%(28/41),差异具有统计学意义(P<0.05);2组症状积分均明显降低(P<0.05),且观察组明显低于对照组(P<0.05);2组患者视觉模拟评分(VAS)较治疗前评分显著下降(P<0.05),且观察组降幅明显大于对照组(P<0.05);2组患者肿瘤坏死因子α(TNF-α)、白细胞介素-1(IL-1)及基质金属蛋白酶-1(MMP-1)水平均较治疗前显著下降(均P<0.05),且观察组下降幅度更大(P<0.05)。结论 中药热奄包联合运动干预可有效治疗膝骨性关节炎,提高患者膝关节功能,减轻疼痛,于其病情转归有利。

Objective To study application of Chinese medicine fomentation package combined with exercise intervention in the treatment of knee osteoarthritis(KOA). Methods Eighty-two KOA patients were randomly divided into observation group(Chinese medicine fomentation package combined with exercise intervention) and control group(exercise intervention). The clinical curative effect, scores of traditional Chinese medicine syndromes, disease pain and levels of inflammation factors were compared between the two groups. Results After treatment, the total effective rate of the two groups was 92.7%(38/41) and 68.3%(28/41), and the difference was statistically significant(P<0.05). The symptom scores of the two groups were significantly decreased(P<0.05), and the observation group was significantly lower than the control group(P<0.05). The visual analogue scale(VAS) score of the two groups was significantly decreased compared with that before treatment(P<0.05), and the decrease in the observation group was significantly greater than that in the control group(P<0.05). Tumor necrosis factor-α(TNF-α) in two groups;The levels of interleukin-1(IL-1) and matrix metalloproteinase-1(MMP-1) were significantly decreased compared with those before treatment(P<0.05), and the decrease was greater in the observation group(P<0.05). Conclusion Chinese medicine fomentation package combined with exercise intervention can effectively treat KOA, improve knee function, alleviate pain, which is beneficial to disease outcomes.