食欲素对恐惧记忆与空间学习记忆调节作用研究进展

Research progress on the regulation of orexin on fear memory and spatial learning and memory

食欲素是参与调节内分泌、自主神经活动和行为反应的重要神经肽,但有关其参与记忆调控机制的报道较少。恐惧记忆可为机体建立预警,食欲素可促进恐惧记忆获取,抑制恐惧记忆消退。空间学习记忆也是影响人体生理活动与日常行为生活的重要记忆类型,脑内正常食欲素水平的维持是空间学习记忆形成的重要保证,而过量的食欲素也会导致空间学习记忆障碍。食欲素分泌受年龄、运动等因素的影响,本文重点梳理食欲素相关调节因素,期待以食欲素为干预靶标,为记忆形成与调控的药物研发提供新思考。

Orexin is an important neuropeptide involved in the regulation of endocrine,autonomic nervous activity and behavioral response,but the mechanism of orexin involved in memory regulation is less reported.Fear memory can establish early warning for the body,orexin can promote fear memory acquisition and inhibit fear memory extinction.Spatial learning and memory is also an important memory type that affects human physiological activities and daily behavior.The maintenance of normal orexin level in the brain is an important guarantee for the formation of spatial learning and memory,and excessive orexin can also lead to spatial learning and memory impairment.Orexin secretion is affected by age,exercise and other factors.This article aims to focus on the regulatory factors related to orexin,and look forward to using orexin as an intervention target to provide new thinking for drug development of memory formation and regulation.