武威市健康人群白喉、百日咳抗体水平回顾性分析

Retrospective Analysis of Diphtheria and Pertussis Antibody Levels in Healthy Population in Wuwei

目的:了解武威市健康人群白喉IgG、百日咳IgG抗体水平,为白喉和百日咳疫情防控提供策略。方法:在2018年11月采集的冻存于-70℃环境的健康人群血清中,随机抽取凉州区和天祝县不同年龄段人群血清检测白喉IgG、百日咳IgG抗体。结果:共检测265份血清,其中白喉IgG抗体阳性率为64.75%,百日咳IgG抗体阳性率为8.68%,白喉IgG抗体阳性率高于百日咳,两种抗体阳性率比较,差异有统计学意义(χ^(2)=107.3613,P<0.05)。不同性别白喉IgG抗体阳性率比较,差异无统计学意义(P>0.05),不同性别百日咳IgG抗体阳性率差异无统计学意义(P>0.05)。凉州区白喉IgG抗体阳性率高于天祝县,差异有统计学意义(χ^(2)=6.527,P<0.05)。凉州区百日咳IgG抗体阳性率与天祝县比较,差异无统计学意义(P>0.05)。结论:武威市尚未形成较为牢固的白喉、百日咳免疫屏障。特别是天祝县4~15岁儿童白百破疫苗免疫还需要加强,要在常规免疫的同时,开展适龄儿童白百破疫苗的查漏补种及入托入学儿童预防接种证查验工作。

OBJECTIVE To understand the antibody level of diphtheria and pertussis among healthy people in Wuwei,and to provide immunization strategies for the prevention and control of Diphtheria and Pertussis.METHODS In November 2018,the Sera of healthy people stored at-70℃were collected,and the Sera of People of Different Ages in Liangzhou District and Bairi Tibetan Autonomous County were randomly selected to detect IgG antibodies against diphtheria and Pertussis.RESULTS 265 Serum samples were tested.The positive rate of Diphtheria IgG antibody and Pertussis IgG antibody were 64.75%and 8.68%,respectively.There was a significant difference between the positive rates of Diphtheria IgG and Pertussis IgG(χ^(2)=107.3613,P<0.05).There was no significant difference in the positive rate of diphtheria IgG antibody between male and female(P>0.05).There was no significant difference in the positive rate of Pertussis IgG antibody(P>0.05).The positive rate of Diphtheria IgG antibody in Liangzhou District was higher than that in Bairi Tibetan Autonomous County(χ^(2)=6.527,P<0.05).There was no significant difference in the positive rate of Pertussis IgG between Liangzhou district and Bairi Tibetan Autonomous County(P>0.05).CONCLUSION Wuwei has not yet formed a relatively strong diphtheria,pertussis immune barrier.In particular,the immunization of children aged 4~15 years old in Bairi Tibetan Autonomous County needs to be strengthened.In addition to routine immunization,efforts should be made to detect and re vaccinate the DPT vaccine for children of the right age and to verify the vaccination certificates of school-going children.