具有骨免疫调节性能的骨科生物材料研究进展

Research progress of orthopedic biomaterials with bone immunomodulatory properties

近年来,各种生物材料在骨科的应用越来越多,大多数骨科生物材料的研究主要关注其直接促成骨作用,却忽视了植入体内后免疫反应对骨整合的影响。许多研究表明免疫系统在调节成骨破骨方面具有重要作用,尤其是巨噬细胞的双重调节作用。一些生物材料通过改变其理化性质或者添加生物活性成份,可以调节植入材料后的免疫反应,从而更好地促进骨整合。本文将对以上问题的相关研究进展进行综述。

In recent years,various biomaterials have been used more and more in orthopedics.Most of the studies on orthopedic biomaterials focus on their direct effect on osteogenesis,but ignore the effect of immune response on osseointegration after implantation.Many studies have shown that the immune system plays an important role in the regulation of osteogenesis and osteoclastogenesis,especially the dual regulation of macrophages.Some biomaterials can regulate the immune response after implantation by changing their physical and chemical properties or adding bioactive ingredients,so as to better promote osseointegration.This paper reviewed the research progress of the above issues.