摘要
以氨基化磁性材料为内核,吲哚乙酸(IAA)为模板分子、甲基丙烯酸(MAA)为功能单体、偶氮二异丁腈(AIBN)为引发剂、乙二醇二甲基丙烯酸酯(EGDMA)为交联剂、乙腈为溶剂制备核壳型磁性分子印迹聚合物(IAA-MMIPs)。探索了模板、功能单体和交联剂的最佳比例及最优聚合时间;通过等温吸附、动力学吸附及人工尿样中对IAA的吸附等实验,对IAA-MMIPs的吸附性能进行评价。结果显示,IAA-MMIPs对IAA有较强的吸附效果,在人工尿样中对IAA的吸附能力显示出较好的应用潜力。
The design and preparation of adsorbent materials for protein-bound uremic toxins,such as indoleacetic acid(IAA),is of interest in the field of hemodialysis.Core-shell magnetic molecularly imprinted polymers(IAA-MMIPs)were prepared with aminoated magnetic materials as cores,IAA as template molecule,methacrylic acid(MAA)as functional monomer,2,2′-azodiisobutyronitrile(AIBN)as initiator,ethylene glycol dimethacrylate(EGDMA)as cross-linker,and acetonitrile as solvent.The optimal ratio of template,functional monomer,and cross-linker and the optimal polymerization time were explored.The adsorption performance of IAA-MMIPs was evaluated by isothermal adsorption,kinetic adsorption,and adsorption of IAA in artificial urine samples.The results showed that IAA-MMIPs had a strong adsorption effect on IAA.The adsorption ability of IAA-MMIPs on IAA in artificial urine samples demonstrated its potential for application in complex sample environments such as hemodialysis.
作者
刘恋
冯淋
乔晨
樊世萌
尤祥宇
苏江涛
LIU Lian;FENG Lin;QIAO Chen;FAN Shi-meng;YOU Xiang-yu;SU Jiang-tao(School of Bioengineering and Food Science,Hubei University of Technology,Wuhan 430068,China)
出处
《化学试剂》
CAS
北大核心
2022年第12期1762-1767,共6页
Chemical Reagents
基金
国家自然科学基金青年科学基金项目(81703409)。
关键词
吲哚乙酸
尿毒症毒素分子
分子印迹
磁性材料
吸附
indoleacetic acid
uremic toxins
molecular imprinting
magnetic material
adsorption
