短链脂肪酸对机体代谢的调控作用

The effects of short chain fatty acids on host metabolism

肠道菌群与人体的健康密切相关,人体为肠道菌群的生长、发育和繁殖提供了稳定的环境,同时肠道菌群也影响着人体的代谢。近年来,随着研究的深入,肠道菌群影响人体代谢的多种途径不断被发现,其中肠道菌群的代谢产物——短链脂肪酸(SCFAs)起着至关重要的作用。短链脂肪酸(SCFAs)可以影响不同组织和器官的生理功能从而调控全身代谢,并且在一些代谢性疾病的治疗上具有广阔的前景。

Growing evidence has revealeda strong association of the gut microbiotawithmetabolic diseases of human beings.Literature has recently proposed an important role for the key metabolites deriving from the gut microbiota,namely short chain fatty acids(SCFAs),to maintain host's metabolic homeostasis.SCFAs regulate systemic metabolism by affecting physiology of different tissues and organs.Moreover,it can be use as therapies for some metabolic diseases with broad prospects.In this Review,we discuss the current findings on how SCFAs contribute to the metabolic health of host.