益肾降糖方治疗肾病综合征合并类固醇糖尿病

Clinical effect of Yishen Jiangtang Recipe in treating nephrotic syndrome complicated with steroid diabetes

目的探讨益肾降糖方治疗肾病综合征合并类固醇糖尿病的临床效果。方法按照随机数表法将82例肾病综合征合并类固醇糖尿病患者分成对照组与观察组。对照组采用常规西药治疗,观察组在对照组基础上给予益肾降糖方治疗,2组均治疗12周。观察2组治疗前后血白蛋白、24h尿蛋白定量、胆固醇水平、血糖水平、血尿素氮、血肌酐的改善状况,比较2组治疗总有效率和安全性。结果观察组治疗后的血白蛋白水平高于对照组(P<0.05);24h尿蛋白定量、总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、空腹血糖、餐后2h血糖、糖化血红蛋白、血尿素氮及血肌酐水平均低于对照组(P<0.05);观察组总有效率(90.24%,37/41)高于对照组(73.17%,30/41)(P<0.05);2组不良反应发生率比较,差异无统计学意义(P>0.05)。结论益肾降糖方联合常规西药治疗肾病综合征合并类固醇糖尿病,能够有效调节血糖和胆固醇水平,降低24h尿蛋白定量,改善肾功能,且不良反应少,疗效显著。

Objective To investigate the clinical effect of Yishen Jiangtang Recipe in treating nephrotic syndrome complicated with steroid diabetes.Methods A total of 82 patients with nephrotic syndrome complicated with steroid diabetes were divided into a control group and an observation group according to the random number table method.The control group was treated with conventional western medicine,while the observation group was treated with Yishen Jiangtang Recipe on the basis of the control group,both for 12 weeks.The improvement of serum albumin,24h urine protein,cholesterol,blood glucose,blood urea nitrogen and serum creatinine before and after treatment were observed,and the total effective rate and safety of the two groups were compared.Results After treatment,the level of serum albumin in the observation group was higher than that in the control group(P<0.05).The levels of 24h urine protein,total cholesterol,low-density lipoprotein cholesterol,high-density lipoprotein cholesterol,fasting blood glucose,2h postprandial blood glucose,glycosylated hemoglobin,blood urea nitrogen and blood creatinine in the observation group were lower than those in the control group(P<0.05).The total effective rate of the observation group(90.24%,37/41)was higher than that of the control group(73.17%,30/41)(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion In the treatment of nephrotic syndrome complicated with steroid diabetes,Yishen Jiangtang Recipe combined with conventional western medicine can effectively regulate the levels of blood glucose and cholesterol,reduce the 24-hour urine protein quantitation,improve the renal function,with less adverse reactions and a significant efficacy.