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温阳利水抗衰方联合达格列净治疗2型糖尿病合并慢性充血性心力衰竭 被引量:3

Effect of Wenyang Lishui Kangshuai Recipe combined with dapagliflozin in the treatment of type 2 diabetes mellitus complicated with chronic congestive heart failure
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摘要 目的观察温阳利水抗衰方联合达格列净治疗2型糖尿病(T2DM)合并慢性充血性心力衰竭患者的临床疗效。方法选择287例2型糖尿病合并慢性充血性心力衰竭患者,按随机分组法分为对照组(n=144)与观察组(n=143),比较2组临床疗效、血糖指标、心功能相关指标、不良反应发生情况。结果观察组有效率(88.81%,127/143)优于对照组(79.16%,114/144)(P<0.05)。治疗后,2组空腹血糖腹血糖(FBG)、餐后2h血糖(2h PBG)、糖化血红蛋白(HbA1c)均低于治疗前,且观察组FBG、2h PBG、HbA1c均低于对照组(P<0.05)。治疗后,2组左心室射血分数(LVEF)、心输出量(CO)均高于治疗前,N端脑纳肽前体(NT-ProBNP)低于治疗前,且观察组LVEF、CO高于对照组,NT-ProBNP低于对照组(P<0.05)。2组恶心呕吐、腹泻、心动过速等不良反应发生情况比较,差异无统计学意义(P>0.05)。结论温阳利水抗衰方联合达格列净治疗2型糖尿病合并慢性充血性心力衰竭患者,临床疗效较好,可以有效降低患者血糖,恢复患者心肌功能,且安全性较高。 Objective To observe the therapeutic effect of Wenyang Lishui Kangshuai Recipe combined with dapagliflozin in the treatment of type 2 diabetes mellitus(T2DM)complicated with chronic congestive heart failure.Methods A total of 287 patients with T2DM and chronic congestive heart failure who were admitted to the hospital between April 2019 and April 2021 were selected,and randomly divided into a control group(n=144)and an observation group(n=143).The clinical effects,blood glucose indicators,cardiac function-associated indicators and adverse reactions were compared between the two groups.Results The effective rate of the observation group(88.81%,127/143)was better than that of the control group(79.16%,114/144)(P<0.05).After treatment,the levels of fasting blood glucose(FBG),2h postprandial blood glucose(2h PBG)and glycosylated hemoglobin(HbA1c)in both groups were lower than those before treatment,and these indicators in the observation group were lower than those in the control group(P<0.05).After treatment,the left ventricular ejection fraction(LVEF)and cardiac output(CO)in both groups were higher than those before treatment,while the N-terminal pro-brain natriuretic peptide(NT-ProBNP)was lower than that before treatment.Meanwhile,the observation group had a higher LVEF and CO,and a lower NT-ProBNP than the control group(P<0.05).There was no significant difference in the occurrence of adverse reactions such as nausea,vomiting,diarrhea and tachycardia between the two groups(P>0.05).Conclusion Wenyang Lishui Kangshuai Recipe combined with dapagliflozin is effective in the treatment of patients with T2DM and chronic congestive heart failure,which can effectively lower blood glucose and restore the myocardial function in the patients,with a higher safety.
作者 高敏 肖明 寇学俊 GAO Min;XIAO Ming;KOU Xuejun(Shandong Provincial Third Hospital,Jinan 250031,China)
出处 《长春中医药大学学报》 2022年第12期1344-1347,共4页 Journal of Changchun University of Chinese Medicine
基金 山东省自然科学基金(ZR2019PH107)。
关键词 2型糖尿病 慢性充血性心力衰竭 温阳利水抗衰方 达格列净 type 2 diabetes mellitus(T2DM) chronic congestive heart failure Wenyang Lishui Kangshuai Recipe dapagliflozin
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