尼麦角林片联合巴曲酶治疗短暂性脑缺血发作的效果

Effect of Nicergoline Tablets Combined With Batroxobin in the Treatment of Transient Ischemic Attack

目的 探讨在短暂性脑缺血发作(TIA)患者中应用尼麦角林片联合巴曲酶的效果。方法 选取我院收治的94例TIA患者,依据随机数字表法分为对照组和观察组,各47例;对照组采用常规+尼麦角林片治疗,观察组采用常规+巴曲酶+尼麦角林片治疗,持续治疗2周。对比两组治疗前和治疗2周时血液流变学指标[全血黏度(WBV)、血浆黏度(PV)、红细胞压积(HCT)、纤维蛋白原(FIB)]和血清学指标[基质金属蛋白酶-9(MMP-9)、血管紧张素Ⅱ(ANGⅡ)、血管内皮生长因子(VEGF)],并对比两组发作次数和持续时间。结果 相较于治疗前,两组治疗2周的WBV、PV、HCT、FIB水平较低,且相较于对照组,观察组较低,差异有统计学意义(P<0.05);相较于治疗前,两组治疗2周的血清ANGⅡ、MMP-9、VEGF水平较低,且相较于对照组,差异有统计学意义(P<0.05);相较于对照组,观察组TIA发作次数较少,持续时间较短,差异有统计学意义(P<0.05)。结论尼麦角林片联合巴曲酶治疗TIA,可改善患者的血液流变血和血清学指标,且可降低TIA的发作次数,缩短症状持续时间。

Objective To investigate the effect of nicergoline tablets combined with batroxobin in patients with transient ischemic attack(TIA).Methods 94 TIA patients were selected and divided into a control group and an observation group according to a random number table method,with 47 cases in each group.The control group was treated with routine + nicergoline tablets,and the observation group was treated with routine + batroxobin + nicergoline tablets,the treatment lasted for 2 weeks.The hemorheological indexes [whole blood viscosity(WBV),plasma viscosity(PV),hematocrit(HCT),fibrinogen(FIB)] and serological indexes [matrix metalloproteinase-9(MMP-9),angiotensin Ⅱ(ANG Ⅱ),vascular endothelial growth factor(VEGF)] of the two groups before treatment and at 2 weeks of treatment were compared,and the times and duration of attack between the two groups were compared.Results Compared with before treatment,the levels of WBV,PV,HCT and FIB in both groups at 2 weeks of treatment were lower,and compared with the control group,the observation group was lower,with statistical significant differences(P<0.05);compared with before treatment,the levels of serum ANG Ⅱ,MMP-9 and VEGF in both groups at 2 weeks of treatment were lower,and compared with the control group,with statistical significant differences(P<0.05);compared with the control group,the times was fewer and duration was shorter of TIA in the observation group,with a statistical significant difference(P<0.05).Conclusion Nicergoline tablets combined with batroxobin in the treatment of TIA can improve the hemorheology and serum indexes of patients,and can reduce the times of TIA and shorten the duration of symptoms.